Angiocentric Glioma

As angiocentric glioma , a rare benign is brain tumor called, who in 2007 in the WHO classification of tumors of the central nervous system was recorded and classified as grade I.

Epidemiology and Clinic

Angiocentric gliomas are rare: fewer than 50 cases have been reported worldwide. They occur particularly in children and young adults; the mean age at diagnosis is 17 years. The tumors are typically located superficially in the area of the cerebral cortex and are clinically noticeable primarily through epileptic seizures . In magnetic resonance imaging , angiocentric gliomas are shown in the FLAIR weighting as well-demarcated hyperintense tumors without contrast agent absorption.

Neuropathology

Histopathologically , angiocentric gliomas are characterized by monomorphic tumor cells with bipolar processes and an angiocentric growth pattern. Immunohistochemically, the tumor cells express the epithelial membrane antigen (EMA) and GFAP , but not neuronal antigens. Mitotic activity is low.

Treatment and prognosis

The surgical removal of the tumor has a favorable effect usually on the seizure frequency from. Recurrences are extremely rare.

literature

Angiocentric glioma. In: Louis, DD, Ohgaki, H., Wiestler, O., Cavenee, eds. World Health Organization classification of tumors. Pathology and genetics of tumors of the nervous system. Lyon, IARC Press; 2007
DN Louis, H. Ohgaki, OD Wiestler, WK Cavenee, PC Burger, A. Jouvet, BW Scheithauer, P. Kleihues: The 2007 WHO classification of tumors of the central nervous system. In: Acta neuropathologica. Volume 114, number 2, August 2007, pp. 97-109, doi : 10.1007 / s00401-007-0243-4 , PMID 17618441 , PMC 1929165 (free full text) (review, with illustration of the histopathology of angiocentric glioma).

Individual evidence

↑ Louis DN, Ohgaki H, Wiestler OD, et al. : The 2007 WHO classification of tumors of the central nervous system . In: Acta Neuropathol . 114, No. 2, August 2007, pp. 97-109. doi : 10.1007 / s00401-007-0243-4 . PMID 17618441 . PMC 1929165 (free full text).
↑ Preusser M, Hoischen A, Novak K, et al. : Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases . In: Am. J. Surg. Pathol . 31, No. 11, November 2007, pp. 1709-18. doi : 10.1097 / PAS.0b013e31804a7ebb . PMID 18059228 .
↑ Wang M, Tihan T, Rojiani AM, et al. : Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma . In: J. Neuropathol. Exp. Neurol . 64, No. 10, October 2005, pp. 875-81. PMID 16215459 .
↑ Lellouch-Tubiana A, Boddaert N, Bourgeois M, et al. : Angiocentric neuroepithelial tumor (ANET): a new epilepsy-related clinicopathological entity with distinctive MRI . In: Brain Pathol . 15, No. 4, October 2005, pp. 281-6. PMID 16389940 .

[1] Louis DN, Ohgaki H, Wiestler OD, et al. : The 2007 WHO classification of tumors of the central nervous system . In: Acta Neuropathol . 114, No. 2, August 2007, pp. 97-109. doi : 10.1007 / s00401-007-0243-4 . PMID 17618441 . PMC 1929165 (free full text).

[2] Preusser M, Hoischen A, Novak K, et al. : Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases . In: Am. J. Surg. Pathol . 31, No. 11, November 2007, pp. 1709-18. doi : 10.1097 / PAS.0b013e31804a7ebb . PMID 18059228 .

[3] Wang M, Tihan T, Rojiani AM, et al. : Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma . In: J. Neuropathol. Exp. Neurol . 64, No. 10, October 2005, pp. 875-81. PMID 16215459 .

[4] Lellouch-Tubiana A, Boddaert N, Bourgeois M, et al. : Angiocentric neuroepithelial tumor (ANET): a new epilepsy-related clinicopathological entity with distinctive MRI . In: Brain Pathol . 15, No. 4, October 2005, pp. 281-6. PMID 16389940 .