WHO classification of tumors of the central nervous system

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The WHO classification of tumors of the central nervous system is a globally used and generally recognized classification of brain tumors of the World Health Organization (WHO).

classification

While the actual WHO classification is merely a list of recognized tumor entities , the accompanying histological definition of the various tumors, together with their immunohistochemical and molecular genetic characteristics, represents an important resource for neuropathological diagnostics and enables consistency and global comparability of neuropathological findings . The grading of the various tumor entities is also of particular clinical importance because of their prognostic information.

Graduation

The histological grading scheme of the WHO classification enables a certain prediction of the biological behavior of a brain tumor across different tumor entities. In the clinical context, the tumor grade is of great importance when deciding whether to opt for adjuvant chemotherapy or radiation therapy .

classification	description	Sample diagnoses
WHO grade I	histologically benign tumors that can usually be cured by surgical removal	Craniopharyngioma , schwannoma , pilocytic astrocytoma
WHO grade II	histologically benign, but often infiltrative growing tumors that tend to recur , but without significantly reducing survival time	Diffuse astrocytoma , oligodendroglioma
WHO grade III	histologically malignant tumors associated with a reduction in survival time	Anaplastic astrocytoma , anaplastic oligodendroglioma , plexus carcinoma
WHO grade IV	extremely malignant tumors that are associated with a significant reduction in survival time if no effective treatment is available	Glioblastoma , medulloblastoma

The WHO grade is only one component among a large number of criteria that ultimately influence the prognosis of a brain tumor. Other important factors include the location of the tumor, the possibility of its complete neurosurgical removal, the response of the tumor to chemotherapy and radiation therapy, and the age of the patient.

history

The decision to create the WHO classification of tumors of the central nervous system goes back to 1956, the first book edition was published in 1979 by Klaus-Joachim Zülch . Over 70 authors from 19 countries contributed to the current 4th edition, which was published in 2007.

literature

• WHO Classification of Tumors of the Central Nervous System. (Eds. Cavenee, Louis, Ohgaki & Wiestler) Lyon, IARC Press, 2007, ISBN 9283224302

Individual evidence

1. ↑ Louis et al .: The 2007 WHO Classification of Tumors of the Central Nervous System. Acta Neuropathol. 2007; 114 (2): 97-109 PMID 17618441
2. ↑ S. Feiden · W. Feidenr: WHO classification of CNS tumors in: Pathologist 2008 29: 411-421. PMID 18820922
3. ↑ The current WHO classification of brain tumors 2007
4. ↑ The current WHO grading of brain tumors 2007

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !