Area composita
The area composita is a heart-specific cell connection that is responsible for the transmission of force between individual heart muscle cells during contraction and is a main component of the so-called glossy stripes . It consists u. a. of typical desmosomal cadherins (Dsg-2, Dsc-2) and typical striped desmosome cadherins ( N-cadherin) and so-called plaque or adapter proteins (e.g. desmoplakin , plakophilin -2, beta- catenin , etc.) on which filaments des Attach the cytoskeleton . All these components do not occur in the mammalian heart in separate structures as in epithelial desmosomes and stripe desmosomes, but are mixed in the area composita in protein complexes.
Individual evidence
- ↑ Franke et al., 2006; Borrmann et al. 2006; Pieperhoff and Franke, 2007; Pieperhoff and Franke, 2008