Asialoglycoprotein Receptors

The asialoglycoprotein receptor binds the galactose residue, the protein can be introduced.

Asialoglycoprotein receptors (ASGP-R) are the natural biological degradation of erythrocytes , as well as glycoproteins of the blood serum involved.

function

If sialic acid residues are split off from oligosaccharide chains of cell wall proteins (or glycoproteins in blood serum) through the enzymatic activity of a neuraminidase in the blood , the now free oligosaccharide chain becomes terminal. Asialoglycoprotein receptors in the cell wall recognize the galactose residues and bind them. Cells marked in this way are then packaged in vesicles and fed to endocytosis (cell digestion). This process is called receptor-mediated endocytosis .

Occurrence

Asialoglycoprotein receptors involved in the breakdown of aging erythrocytes occur mainly in macrophages of the spleen , whereas the receptors involved in the breakdown of extracellular glycoproteins are mainly located in the hepatocytes of the liver .

literature

• Jeremy M. Berg, John L. Tymotzko, Lubert Stryer: Biochemistry . Spektrum Akademischer Verlag, 5th edition (April 2003), ISBN 3827413036