Atlas of Genetics and Cytogenetics in Oncology and Hematology

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The Atlas of Genetics and Cytogenetics in Oncology and Hematology ( "Atlas of Genetics and Cytogenetics in Oncology and Hematology ") is an Internet-based online -resource, Encyclopedia and database for the genetics of malignant diseases.

history

The atlas was founded in 1997 by the French geneticist Jean-Loup Huret ( Center hospitalier universitaire de Poitiers ), who has been responsible for the atlas scientifically to this day (2019). The initiative for the establishment of the atlas came from the environment of the French Association for Tumor Cytogenetics ( Groupe Français de Cytogénétique Oncologique , GFCO), which participated in the design of the project. The aim of the project was to build a freely accessible online database for cytogenetic and genetic changes in tumors.

Contributions to genes, chromosomal aberrations and genetic syndromes relevant to cancer have been included in the atlas . The contributions were written by various scientists. Submitted contributions are subjected to a peer review process before they are published. The atlas also acts as online - open access journal ( ISSN 1768-3262). All contributions are written in English.

As of the end of 2012, the atlas contained articles on 1135 genes, 503 hematological and 117 solid tumor diseases, as well as 104 genes that play a role in the predisposition to cancer. It also contained “automated maps” of 8190 genes that potentially play a role in cancer. These “automated maps” were bioimformatically generated without peer review by filtering and compiling information from other databases. The aim is to provide an automatic map for all approx. 30,000 genes in the human genome.

The atlas is dependent on donations from private individuals and scientific associations for its continued existence and further development.

Web links

Individual evidence

  1. ↑ F. Dorkeld, A. Bernheim, P. Dessen, JL Huret: A database on cytogenetics in haematology and oncology . In: Nucleic Acids Res . tape 27 , no. 1 , January 1, 1999, p. 353–354 , doi : 10.1093 / nar / 27.1.353 (English).
  2. ↑ JL Huret, P. Dessen, A. Bernheim: Atlas of Genetics and Cytogenetics in Oncology and Haematology, updated . In: Nucleic Acids Res . tape 29 , no. 1 , 2001, p. 303-304 , PMID 11125120 (English).
  3. ↑ a b Comprendre le Cancer pour sauver de vies. chromosomesincancer.org, accessed April 14, 2019 (English, French).
  4. ^ E. De Braekeleer, JL Huret, H. Mossafa, P. Dessen: Cytogenetic Resources and Information . In: T. Wan (Ed.): Cancer Cytogenetics. Methods in Molecular Biology . tape 1541 . Humana Press, New York 2017, pp. 311–331 , doi : 10.1007 / 978-1-4939-6703-2_25 (English).
  5. ↑ Jean-Loup Huret, Mohammad Ahmad, Mélanie Arsaban, Alain Bernheim, Jérémy Cigna, François Desangles, Jean-Christophe Guignard, Marie-Christine Jacquemot-Perbal, Maureen Labarussias, Vanessa Leberre, Anne Malo, Catherine Morel-Pair, Hossein Mossafa, Jean-Claude Potier, Guillaume Texier, Franck Viguié, Sylvie Yau Chun Wan-Senon, Alain Zasadzinski, Philippe Dessen: Atlas of Genetics and Cytogenetics in Oncology and Haematology in 2013 . In: Nucleic Acids Research . tape 41 , D1, January 1, 2013, p. D920 – D924 , doi : 10.1093 / nar / gks1082 (English).