Axial spondyloarthritis

The articles ankylosing spondylitis and axial spondyloarthritis overlap thematically. Help me to better differentiate or merge the articles (→  instructions ) . To do this, take part in the relevant redundancy discussion . Please remove this module only after the redundancy has been completely processed and do not forget to include the relevant entry on the redundancy discussion page{{ Done | 1 = ~~~~}}to mark. Nescimus ( discussion ) 21:11, Feb. 22, 2019 (CET)

Classification according to ICD-10
M45.-	Ankylosing spondylitis (Proposed new name: Axial Spondyloarthritis (axSpA))
ICD-10 online (WHO version 2019)

Axial spondyloarthritis (often abbreviated as axSpA ) is a chronic autoimmune disease from the group of spondyloarthritis , which mainly affects the axial skeleton ( lumbar and thoracic spine , as well as the sacro-iliac joints ). The best-known member of the axial spondyloarthritis family is ankylosing spondylitis , which is also known as Bechterew's disease in German-speaking countries .

Axial spondyloarthritis is a collective term that was introduced in 2009 to describe a diverse family of diseases that share many clinical and genetic characteristics.

The term was introduced in order to combine the following clinical pictures: (1) less pronounced forms of spondylitis, (2) early stages of ankylosing spondylitis and (3) ankylosing spondylitis itself.

Reasons for the new term axial spondyloarthritis

In 1984 joint efforts led to the establishment of specific diagnostic criteria for ankylosing spondylitis, known as the Modified New York Criteria . One of the key criteria of New York was that the sickness fusion, erosion and / or formation of bone in the spine or in the sacroiliac joints for a diagnosis radiologically detected had. Even if these criteria lead to a better diagnosis of ankylosing spondylitis, radiological changes usually only manifest themselves several years after the first symptoms have appeared. In order to shorten the time between the first symptoms and diagnosis, new criteria were needed that allow the disease to be recognized at an early stage. In 2009, the modified New York criteria were expanded to include a wide range of new diagnostic criteria which established a diagnosis based on typical spondyloarthritis disease characteristics. These included inflammatory back pain, a family history of axial spondyloarthritis, response to treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), previous inflammation (s) in the joints, heels, tendons, or eyes, signs of increased inflammation ( C-reactive protein, and blood sedimentation) ) and other typical spondyloarthritis features. If these criteria still do not produce a convincing clinical picture, the HLA-B27 biomarker and magnetic resonance imaging (MRT) must also be included in the diagnosis. Because ankylosing spondylitis disease was still defined by the modified 1984 New York criteria, there was a need to find a new disease term that would include the less severe forms and the early stages of ankylosing spondylitis cases. This term was found in the collective term axial spondyloarthritis.

nomenclature

Axial spondyloarthritis can be divided into two classes:

1. Non-radiological axial spondyloarthritis (nr-axSpA):
   This term includes both the early stage of ankylosing spondylitis , in which no radiological changes are visible, as well as less severe forms of ankylosing spondylitis.
2. Radiological axial spondyloarthritis:
   synonymous with ankylosing spondylitis . This class is known as radiographic axial spondyloarthritis because the diagnosis is based on finding clear radiographic changes in the spine or the sacrum .

Web links

• Martin Rudwaleit, Joachim Sieper: Diagnosis and early diagnosis of ankylosing spondylitis (Bechterew's disease) , especially p. 7f .: The concept of "axial spondyloarthritis". 2005

Individual evidence

1. ↑ DIMDI ( Memento of the original from March 5, 2017 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
2. ↑ ^{a b c d} M Rudwaleit, D van der Heijde, R Landewe, J Listing, N Akkoc, J Brandt, J Braun, CT Chou, E Collantes-Estevez, M Dougados, F Huang, J Gu, MA Khan, Y Kirazli , WP Maksymowych, H Mielants, IJ Sorensen, S Ozgocmen, E Roussou, R Valle-Onate, U Weber, J Wei, J Sieper: The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection . In: Annals of the Rheumatic Diseases . 68, No. 6, 2009, ISSN  0003-4967 , pp. 777-783. doi : 10.1136 / ard.2009.108233 .
3. ^ Sjef Van Der Linden, Hans A. Valkenburg, Arnold Cats: Evaluation of Diagnostic Criteria for Ankylosing Spondylitis . In: Arthritis & Rheumatism . 27, No. 4, 1984, ISSN  0004-3591 , pp. 361-368. doi : 10.1002 / art.1780270401 .
4. ↑ ^{a b} Joel D. Taurog, Dan L. Longo, Avneesh Chhabra, Robert A. Colbert: Ankylosing spondylitis and axial spondyloarthritis . In: New England Journal of Medicine . 374, No. 26, 2016, ISSN  0028-4793 , pp. 2563-2574. doi : 10.1056 / NEJMra1406182 .
5. ↑ ^{a b} Denis Poddubnyy, Astrid van Tubergen, Robert Landewé, Joachim Sieper, Désirée van der Heijde: Development of an ASAS-endorsed recommendation for the early referral of patients with a suspicion of axial spondyloarthritis . In: Annals of the Rheumatic Diseases . 74, No. 8, 2015, ISSN  0003-4967 , pp. 1483–1487. doi : 10.1136 / annrheumdis-2014-207151 .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !