BMI-1

BMI-1
	according to PDB 2CKL
other names	PCGF4, RNF51, FLVI2 / BMI1,
	Existing structural data : PDB 2H0D , PDB 2NA1 , PDB 3RPG
Properties of human protein
Mass / length primary structure	326 amino acids , 36,949 Da
Identifier
External IDs	GeneCards : BMI1 ; OMIM : 164831 ; UniProt : P35226 ;
	Orthologue (human)
Entrez	648
Ensemble	ENSG00000168283
UniProt	P35226
Refseq (mRNA)	NM_005180.9
Refseq (protein)	NP_005171.4
PubMed search	648

BMI-1 is a protein in human cells that belongs to the Polycomb group and is involved in the epigenetic regulation of genes in the cell nucleus . Synonyms for BMI-1 are Polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51). In the human genome, BMI-1 is encoded by the BMI1 gene. BMI1 is the human homologue to the mouse gene Bmi1, which was originally identified as an integration site for a mouse leukemia virus (B cell-specific Moloney murine leukemia virus integration site). BMI1 has also been shown to be proto-oncogene in some forms of cancer in humans .

Individual evidence

↑ Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M: Characterization and chromosomal localization of the human proto-oncogene BMI-1 In: Hum. Mol. Genet. Volume 2, Number 10, October 1993, pp. 1597-603. PMID 8268912 .
↑ Siddique HR, Saleem M: Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. In: Stem Cells Volume 30, Number 3, March 2012, pp. 1597-603. PMID 22252887 .

[PMID8268912-1] Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M: Characterization and chromosomal localization of the human proto-oncogene BMI-1 In: Hum. Mol. Genet. Volume 2, Number 10, October 1993, pp. 1597-603. PMID 8268912 .

[PMID22252887-2] Siddique HR, Saleem M: Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. In: Stem Cells Volume 30, Number 3, March 2012, pp. 1597-603. PMID 22252887 .