BMI-1
BMI-1 | ||
---|---|---|
according to PDB 2CKL | ||
other names |
PCGF4, RNF51, FLVI2 / BMI1, |
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Properties of human protein | ||
Mass / length primary structure | 326 amino acids , 36,949 Da | |
Identifier | ||
External IDs | ||
Orthologue (human) | ||
Entrez | 648 | |
Ensemble | ENSG00000168283 | |
UniProt | P35226 | |
Refseq (mRNA) | NM_005180.9 | |
Refseq (protein) | NP_005171.4 | |
PubMed search |
648
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BMI-1 is a protein in human cells that belongs to the Polycomb group and is involved in the epigenetic regulation of genes in the cell nucleus . Synonyms for BMI-1 are Polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51). In the human genome, BMI-1 is encoded by the BMI1 gene. BMI1 is the human homologue to the mouse gene Bmi1, which was originally identified as an integration site for a mouse leukemia virus (B cell-specific Moloney murine leukemia virus integration site). BMI1 has also been shown to be proto-oncogene in some forms of cancer in humans .
Individual evidence
- ↑ Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M: Characterization and chromosomal localization of the human proto-oncogene BMI-1 In: Hum. Mol. Genet. Volume 2, Number 10, October 1993, pp. 1597-603. PMID 8268912 .
- ↑ Siddique HR, Saleem M: Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. In: Stem Cells Volume 30, Number 3, March 2012, pp. 1597-603. PMID 22252887 .