Binding coefficient

The binding coefficient (synonymous coefficient of preferential interaction , English preferential interaction coefficient ) describes in physical chemistry and biochemistry the extent of the bond between a macromolecule such as a protein and the small molecules of a mixture of solvents ( solvent and cosolvent ) according to the Kirkwood-Buff theory .

properties

The binding coefficient can be derived from the Kirkwood-Buff theory. The preferred interaction is defined as a thermodynamic term that describes the bond between the two solvents (solvent and cosolvent). The binding coefficient is a measure of the interactions between dissolved components.

literature

Eli Ruckenstein: Thermodynamics of Solutions. Springer Science & Business Media, 2009, ISBN 978-1-4419-0440-9 , p. 268 ( limited preview in Google book search).
P. Somasundaran: Encyclopedia of Surface and Colloid Science. CRC Press, 2006, ISBN 978-0-8493-9574-1 , p. 5300 ( limited preview in Google book search).
Charles P. Woodbury: Introduction to Macromolecular Binding Equilibria. CRC Press, 2007, ISBN 978-1-4200-5299-2 , p. 114 ( limited preview in Google book search).
VA Parsegian: Protein-water interactions. . In: International Review of Cytology . 215, 2002, pp. 1-31. doi : 10.1016 / S0074-7696 (02) 15003-0 .

Individual evidence

↑ J. Michael Schurr, David P. Rangel, Sergio R. Aragon: A Contribution to the Theory of Preferential Interaction Coefficients . In: Biophysical Journal . tape 89 , no. 4 , October 2005, p. 2258-2276 , doi : 10.1529 / biophysj.104.057331 .
↑ Ivan L. Shulgin, Eli Ruckenstein: A Protein Molecule in a Mixed Solvent: The Preferential Binding Parameter via the Kirkwood-Buff Theory . In: Biophysical Journal . tape 90 , no. 2 , January 15, 2006, p. 704-707 , doi : 10.1529 / biophysj.105.074112 , PMID 16272443 , PMC 1367075 (free full text).
↑ Veronica Pierce, Myungshim Kang, Mahalaxmi Aburi, Samantha Weerasinghe, Paul E. Smith: Recent Applications of Kirkwood-Buff Theory to Biological Systems . In: Cell biochemistry and biophysics . tape 50 , no. 1 , 2008, p. 1–22 , doi : 10.1007 / s12013-007-9005-0 , PMID 18043873 .
↑ MT Record Jr, CF Anderson: Interpretation of preferential interaction coefficients of nonelectrolytes and of electrolyte ions in terms of a two-domain model . In: Biophysical Journal . tape 68 , no. 3 , March 1995, p. 786-794 , doi : 10.1016 / S0006-3495 (95) 80254-7 .

[1] J. Michael Schurr, David P. Rangel, Sergio R. Aragon: A Contribution to the Theory of Preferential Interaction Coefficients . In: Biophysical Journal . tape 89 , no. 4 , October 2005, p. 2258-2276 , doi : 10.1529 / biophysj.104.057331 .

[2] Ivan L. Shulgin, Eli Ruckenstein: A Protein Molecule in a Mixed Solvent: The Preferential Binding Parameter via the Kirkwood-Buff Theory . In: Biophysical Journal . tape 90 , no. 2 , January 15, 2006, p. 704-707 , doi : 10.1529 / biophysj.105.074112 , PMID 16272443 , PMC 1367075 (free full text).

[3] Veronica Pierce, Myungshim Kang, Mahalaxmi Aburi, Samantha Weerasinghe, Paul E. Smith: Recent Applications of Kirkwood-Buff Theory to Biological Systems . In: Cell biochemistry and biophysics . tape 50 , no. 1 , 2008, p. 1–22 , doi : 10.1007 / s12013-007-9005-0 , PMID 18043873 .

[4] MT Record Jr, CF Anderson: Interpretation of preferential interaction coefficients of nonelectrolytes and of electrolyte ions in terms of a two-domain model . In: Biophysical Journal . tape 68 , no. 3 , March 1995, p. 786-794 , doi : 10.1016 / S0006-3495 (95) 80254-7 .