Bowenoid papulosis

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Classification according to ICD-10
D06 Carcinoma in situ of the cervix uteri
D07 Carcinoma in situ of other and unspecified genital organs
ICD-10 online (WHO version 2019)

The bowenoid papulosis ( Condylomata plana ) is a skin infection with human papillomavirus (HPV) in the genital area, which (to characteristic nodular papular leads lesions).

Pathogen

The causative agents of this infectious skin disease are human papilloma viruses of group 16 or 18, as well as 31, 33. These viral serotypes (sub-forms of certain viruses) are called high -risk types (high-risk types), which means that there is a risk of an infection with these Viruses can turn into a cancerous growth, compared to the other subtypes is increased. Those affected are mostly 20 to 40 year olds.

Since 90% of cervical dysplasia papillomavirus DNA could be detected this high-risk types, it is believed that these viruses also involved in the pathogenesis of cervical and penile cancer are involved.

Symptoms

The clinical examination reveals variously shaped red-brown, pin to lens-sized, flat, velvety papules . These are mainly located in the area of ​​the glans penis and the small and large labia . The skin changes are not painful and there is no itching. A transition to vulvar and penile carcinomas is possible.

Diagnosis

Altered ( dyskeratotic ) cells in the dermis ( skin layers ) in the histopathological examination correspond to a carcinoma in situ (similar to Bowen's disease ) and confirm the diagnosis.

therapy

The therapy of choice is the ablation of the bowenoid papulosis using a carbon dioxide laser or electrocautery , diathermy or curettage are also possible. Because of the potential for malignant degeneration, careful follow-up checks and long-term monitoring should be carried out. In the case of repeated recurrences of the bowenoid papules, a change in the "terrain conditions" by circumcision should be aimed for.

Individual evidence

  1. ↑ Peter Altmeyer: Bowenoide Papulosis In: Dermatologische Differentialdiagnose: The way to clinical diagnosis , Springer Verlag 2011; P. 551. ISBN 978-3-540-39001-5 .

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