burst size

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The burst size describes the number of newly formed virions in an infected host cell .

properties

The burst size depends , among other things, on the virus type , the infected host species , the cell type within the host species, the absence of antivirals and the general nutritional and health status of the infected cell. The number of infected cells in an organism and the respective burst size affect the virus titer and possibly the viral load in this organism. If the multiplicity of infection is high , the burst size can be influenced.

Examples

The influenza virus generates burst sizes in embryonated chicken eggs or cell cultures of around 1,000 to around 19,000 daughter virions per infected cell ; with SIV , the burst sizes range from 13,000 to 59,000 virions per infected cell.

literature

  • Susanne Modrow, Dietrich Falke , Uwe Truyen: Molecular Virology. An introduction for biologists and medical professionals. 2nd Edition. Spectrum textbook, Heidelberg 2002, ISBN 3-8274-1086-X . (with references, English translation 2006) .
  • David M. Knipe, Peter M. Howley, et al. (eds.): Fields' Virology . (2 volumes; standard work on virology) 5th edition, Lippincott Williams & Wilkins, Philadelphia 2007, ISBN 978-0-7817-6060-7 .

Individual evidence

  1. ↑ KW Cummings, DN Levy, D. Wodarz: Increased burst size in multiply infected cells can alter basic virus dynamics. In: Biology direct. Volume 7, 2012, ISSN  1745-6150 , p. 16, doi : 10.1186 / 1745-6150-7-16 , PMID 22569346 , PMC 3482397 (free full text).
  2. ↑ SJ Stray, GM Air: Apoptosis by influenza viruses correlates with efficiency of viral mRNA synthesis. In: Virus research. Volume 77, Number 1, September 2001, ISSN  0168-1702 , pp. 3-17, PMID 11451482 .
  3. ↑ L. Möhler, D. Flockerzi, H. Sann, U. Reichl: Mathematical model of influenza A virus production in large-scale microcarrier culture. In: Biotechnology and bioengineering. Volume 90, Number 1, April 2005, ISSN  0006-3592 , pp. 46-58, doi : 10.1002 / bit.20363 , PMID 15736163 .
  4. ^ HJ Cairns, M. Edney, S. Fazekas de St Groth: Quantitative aspects of influenza virus multiplication. In: Journal of Immunology (Baltimore, Md.: 1950). Volume 69, Number 2, August 1952, ISSN  0022-1767 , pp. 155-181, PMID 14946411 .
  5. ^ HY Chen, M. Di Mascio, AS Perelson, DD Ho, L. Zhang: Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. In: Proceedings of the National Academy of Sciences . Volume 104, number 48, November 2007, ISSN  1091-6490 , pp. 19079-19084, doi : 10.1073 / pnas.0707449104 , PMID 18025463 , PMC 2141911 (free full text).