CCL17

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CCL17 is a cytokine in the chemotactic cytokine ( chemokine ) family and is also known as thymic activity-regulated chemokine (TARC). It is continuously produced in organs of the immune system, in the thymus and temporarily in single-cell, stimulated blood cells. Through a specific binding, with the help of the chemokine receptor CCR4, it binds to T cells and thereby influences their direction of movement ( chemotaxis ). According to the latest findings, CCL17 occurs in high concentrations in damaged tissue in arteriosclerosis in the human body and is responsible for the targeted movement (recruitment) of T lymphocytes into this tissue. The genes for the chemokine are in humans on the chromosome 16 located.

literature

  • C. Weber, S. Meiler, A. Zernecke et al .: CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. In: The Journal of Clinical Investigation. 121 (7), June 1, 2011, pp. 2898-2910. doi: 10.1172 / JCI44925 . PMC 3223829 (free full text).

Individual evidence

  1. ↑ T. Imai, T. Yoshida, M. Baba, M. Nishimura, M. Kakizaki, O. Yoshie: Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. In: J. Biol. Chem. 271 (35), 1996, pp. 21514-21521. doi: 10.1074 / jbc.271.35.21514 . PMID 8702936 .
  2. ↑ T. Imai, M. Baba, M. Nishimura, M. Kakizaki, S. Takagi, O. Yoshie: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. In: J. Biol Chem. 272 (23), 1997, pp. 15036-15042. doi: 10.1074 / jbc.272.23.15036 . PMID 9169480 .
  3. ↑ C. Weber, S. Meiler, A. Zernecke et al .: CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. In: The Journal of Clinical Investigation. 121 (7), 2011, pp. 2898-2910. doi: 10.1172 / JCI44925
  4. ↑ H. Nomiyama, T. Imai, J. Kusuda, R. Miura, DF Callen, O. Yoshie: Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. In: Cytogenet. Cell Genet. 81 (1), 1998, pp. 10-11. doi: 10.1159 / 000015000 . PMID 9691168 .