CCL8

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CCL8
CCL8
according to PDB  1ESR
other names

Chemokine (CC Motif) ligand 8

  • SCYA8
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2)
  • Monocyte Chemoattractant Protein 2
  • Monocyte Chemotactic Protein 2
  • SCYA10
  • HC14
  • CC Motif Chemokine 8

Existing structural data : 1ESR

Properties of human protein
Mass / length primary structure 99 amino acids, 11246 Da
Identifier
External IDs

CCL8 ( English CC-chemokine ligand 8 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL8 is involved in inflammatory processes. It is chemotactic for and activates various immune cells , including mast cells , eosinophils and basophils , monocytes , T cells, and NK cells . CCL8 binds to the chemokine receptors CCR1 , CCR2B and CCR5 . Because it binds to the core receptor of HIV- 1, CCR5, CCL8 inhibits infection of cells with HIV-1.

Individual evidence

  1. ^ Proost P, Wuyts A, Van Damme J: Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1 . In: J. Leukoc. Biol . 59, No. 1, January 1996, pp. 67-74. PMID 8558070 .
  2. ↑ a b Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM: Monocyte chemotactic protein-2 activates CCR5 and blocks CD4 / CCR5-mediated HIV-1 entry / replication . In: J. Biol. Chem. . 273, No. 8, February 1998, pp. 4289-92. doi : 10.1074 / jbc.273.8.4289 . PMID 9468473 .
  3. ↑ J. Blaszczyk, EV Coillie, P. Proost, JV Damme, G. Opdenakker, DG Bujacz, JM Wang, X. Ji: Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine did inter acts with multiple receptors. In: Biochemistry. Volume 39, Number 46, November 2000, pp. 14075-14081, PMID 11087354 .