CCR1

from Wikipedia, the free encyclopedia
CC chemokine receptor type 1
other names

HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R

Existing structure data : PDB  1Y5D

Properties of human protein
Mass / length primary structure 355 amino acids , 41,173 Da
Identifier
External IDs
Orthologue (human)
Entrez 1230
Ensemble ENSG00000163823
UniProt P32246
Refseq (mRNA) NM_001295.2
Refseq (protein) NP_001286.1
PubMed search 1230

CC chemokine receptor type 1 (CCR1) is a surface protein from the group of chemokine receptors .

properties

CCR1 is a G protein-coupled receptor and is produced by various hematopoietic cells. It binds CC-type chemokines such as MIP-1-alpha (CCL3), MIP-1-delta , RANTES (CCL5) and MCP-3 (CCL7). With lower affinity is MIP-1-beta and MCP-1 bound. After binding, the cellular concentration of the second messenger Ca 2+ increases . CCR1 is glycosylated and phosphorylated .

CCR1 is being studied for the treatment of autoimmune and infectious diseases .

Web links

Individual evidence

  1. ↑ A. Karash, MR Mazzoni, A. Gilchrist: Pharmacological intervention at CCR1 and CCR5 as an approach for cancer: help or hindrance. In: Current topics in medicinal chemistry. Volume 14, Number 13, 2014, pp. 1553-1573, PMID 25159162 .
  2. ↑ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J: Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils . In: European Journal of Immunology . 31, No. 7, July 2001, pp. 2170-8. doi : 10.1002 / 1521-4141 (200107) 31: 7 <2170 :: AID-IMMU2170> 3.0.CO; 2-D . PMID 11449371 .
  3. ↑ Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A , Marchant D, Clapham PR, Wells TN: The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity . In: The Journal of Biological Chemistry . 276, No. 14, April 2001, pp. 10620-6. doi : 10.1074 / jbc.M010867200 . PMID 11116158 .
  4. ^ HW Zimmermann, V. Sterzer, H. Sahin: CCR1 and CCR2 antagonists. In: Current topics in medicinal chemistry. Volume 14, Number 13, 2014, pp. 1539-1552, PMID 25159163 .