CCR3

CC chemokine receptor type 3
other names	Eosinophil eotaxin receptor, CD antigen CD193
Properties of human protein
Mass / length primary structure	355 amino acids , 41,044 Da
Identifier
External IDs	GeneCards : CCR3 ; UniProt : P51677 ;
	Orthologue (human)
Entrez	1232
Ensemble	ENSG00000183625
UniProt	P51677
Refseq (mRNA)	NM_001164680.1
Refseq (protein)	NP_001158152.1
PubMed search	1232

CC chemokine receptor type 3 (CCR3) is a surface protein from the group of chemokine receptors .

properties

CCR3 is a G-protein-coupled receptor and is produced by eosinophils and, in very small quantities, by neutrophils and monocytes . It binds CC-type chemokines , including eotaxin , eotaxin-3 , MCP-3 , MCP-4 , RANTES and MIP-1 delta . After activation, the intracellular concentration of calcium ions increases . In HIV 1 infection, CCR3 is an alternative coreceptor with CD4 . An over-expression of CCR3 in epithelial cells of the intestine is typical at a ulcerative colitis . CCR3 has disulfide bridges .