CD44 antigen
| CD44 antigen | ||
|---|---|---|
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| according to PDB 1POZ | ||
| other names |
CDw44, Epican, Extracellular matrix receptor III, ECMR-III |
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| Properties of human protein | ||
| Mass / length primary structure | 742 amino acids , 81,538 Da | |
| Identifier | ||
| External IDs | ||
CD44 antigen is a surface protein .
properties
CD44 is a receptor for hyaluronic acid and thus mediates cell contacts and contacts to the extracellular matrix . It also binds osteopontin , collagens and matrix metalloproteinases . CD44 is involved in cytokinesis , the activation of lymphocytes , hematopoiesis and the formation of tumors . CD44 amplifies the EGF receptor signaling pathway. It has many isoforms and various post-translational modifications . CD44 is glycosylated , phosphorylated and has a pyrrolidone carboxylic acid .
Web links
Individual evidence
- ^ R. Thapa, GD Wilson: The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in Cancer. In: Stem cells international. Volume 2016, 2016, p. 2087204, doi : 10.1155 / 2016/2087204 , PMID 27200096 , PMC 4856920 (free full text).
- ↑ H. Xu, Y. Tian, X. Yuan, H. Wu, Q. Liu, RG Pestell, K. Wu: The role of CD44 in epithelial-mesenchymal transition and cancer development. In: OncoTargets and therapy. Volume 8, 2015, pp. 3783-3792, doi : 10.2147 / OTT.S95470 , PMID 26719706 , PMC 4689260 (free full text).