Calbindin

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Calbindin
Calbindin
Ribbon model (with its own color for each EF hand motif) according to PDB  2F33
Properties of human protein
Mass / length primary structure 260 amino acids
Identifier
Gene name CALB1
External IDs
Occurrence
Homology family CALB
Parent taxon Jaws

Calbindin (CALB) (more precisely calbindin-D (28k) ) is a protein that binds calcium ions and can thus function as a transport protein for them. It developed with the jaws of the mouth and is found in humans in the intestines , kidneys , islet cells and brain . It is still unclear whether calbindin has other functions beyond its role as a calcium buffer.

Expression in the gut of calbindin can in chickens ( Gallus gallus ) by vitamin D -Gabe be increased. In contrast, expression in the brain is independent of vitamins; there it is associated in particular with interneurons and the Purkinje cells . Calbindin immunassays are therefore used to label such cells. In rats, calbindin expression in the brain was dependent on steroid hormones , especially in female animals.

The molecule has four binding sites for calcium and can therefore transport as many ions. It has five EF-Hand domains.

Individual evidence

  1. JJ Barski, J. Hartmann u. a .: Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. In: The Journal of neuroscience: the official journal of the Society for Neuroscience. Volume 23, Number 8, April 2003, pp. 3469-3477, ISSN  1529-2401 . PMID 12716955 .
  2. Calbindin.  In: Online Mendelian Inheritance in Man . (English).
  3. Stuart EB, Thompson JM, Rhees RW, Lephart ED: Steroid hormone influence on brain calbindin-D (28K) in male prepubertal and ovariectomized rats . In: Brain Res Dev Brain Res... . 129, No. 2, August 2001, pp. 125-133. PMID 11506857 .
  4. UniProt P05937 .