Catharanthus alkaloids

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Pink Catharanthe ( Catharanthus roseus )

Catharanthus alkaloids are natural substances of the indole alkaloid type. You can z. B. Extractively obtain from the shrub Pink Catharanthe ( Catharanthus roseus ) native to Madagascar .

Occurrence

In Catharanthus roseus (formerly Vinca rosea), a shrub native to Madagascar.

Representative

So far, over 70 Catharanthus alkaloids have been isolated from the Catharanthus roseus shrub . The main alkaloids of the plant are catharanthine and vindoline .

The commercially most important Catharanthus alkaloids are vinblastine and vincristine , which are created by linking catharanthine and vindoline derivatives.

  • Catharanthin

  • Vinblastine

  • Vincristine

  • Vindoline

properties

Catharanthin has a blood sugar lowering and diuretic effect. Vincamine is used to treat circulatory disorders in the brain. Vinblastine acts as a mitosis inhibitor and inhibits DNA polymerase. Vincristine is also mitosis-inhibiting and also disrupts RNA synthesis (transcription). Vinblastine and vincristine are also used to treat leukemia and other forms of cancer, as well as Hodgkin's disease.

Individual evidence

  1. ↑ a b c d P. Nuhn: Naturstoffchemie . 4th edition. S. Hirzel Verlag, Stuttgart 2006, ISBN 978-3-7776-1363-5 , p. 612 f .
  2. ↑ a b c Entry on Catharanthus alkaloids. In: Römpp Online . Georg Thieme Verlag, accessed on April 20, 2020.
  3. ↑ E. Breitmaier: Alkaloids . Springer Fachmedien, Wiesbaden 1997, ISBN 978-3-519-03542-8 , pp. 51 f .
  4. ↑ G. Habermehl, P. Hammann, H. Krebs: Naturstoffchemie . 2nd Edition. Springer-Verlag, Berlin Heidelberg 2002, ISBN 978-3-540-43952-3 , p. 200 .