Cephalotaxus alkaloids

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Japanese head yew ( Cephalotaxus harringtonia )
The seeds of the Japanese head pear ( Cephalotaxus harringtonia ), completely covered by the aril, are ripe.

Cephalotaxus alkaloids are natural products with a pentacyclic structure.

Occurrence

Cephalotaxus alkaloids are in the cephalotaxus ( Cephalotaxus before), in particular in the Japanese plum yew .

Representative

The most important representative is cephalotaxin . Further representatives are u. a. Harringtonine and homoharringtonine .

  • (-) - cephalotaxine

  • (-) - Harringtonin

  • (-) - Homoharringtonine

properties

Harringtonine and homoharringtonine show antitumor activity and act against murine leukemia cells. They serve as protein and DNA biosynthesis inhibitors and are used against acute myelocytoxic leukemia.

Individual evidence

  1. ↑ a b c Entry on Cephalotaxus alkaloids. In: Römpp Online . Georg Thieme Verlag, accessed on May 5, 2020.