Chondrosarcoma
| Classification according to ICD-10 | |
|---|---|
| C41.9 | Malignant neoplasm: bone and articular cartilage, unspecified |
| ICD-10 online (WHO version 2019) | |
A chondrosarcoma is a malignant bone tumor , the cells of which form a cartilage matrix, but unlike osteosarcoma, they do not form any bone substance (osteoid). In contrast to the chondroma , the chondrosarcoma has a greater number of cells, pleomorphism and nuclear atypia .
Epidemiology
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Chondrosarcoma is the second most common malignant bone tumor. Its incidence increases with age and peaks around the 6th decade of life. More men than women are affected. The tumor preferably occurs in the pelvic bones and on the femur near the trunk.
The chondrosarcoma hardly causes any pain. Metastases occur late. The risk of metastases correlates with the degree of dedifferentiation. G1 tumors very rarely metastasize.
therapy
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Therapy is a domain of surgery and consists of resection of the tumor. Amputations are only necessary for dedifferentiated (highly malignant) forms and joint involvement. Modern tumor endoprosthetics can also help in such cases. In the case of incisional biopsies, the biopsy channel must be removed, otherwise there is a risk of implantation metastases. The tumor is usually only slightly sensitive to radiation.
Neither chemotherapy nor radiation therapy are promising options. When the chondrosarcomas, which are usually differentiated, are completely resected, life expectancy remains unchanged. With optimal therapy, the five-year survival rate is around 50%.
Web links
Individual evidence
- ↑ a b c d G. Jundt: Bones in W. Böcker, H. Denk, Ph. U. Heitz, H. Moch: Pathologie , 4th edition, Munich, 20908 pp. 1081f
- ↑ Orthopedic Clinic and Polyclinic of the University of Munich: Tumorendoprothetik , accessed on November 4, 2012.
- ↑ a b Jürgen Krämer, Joachim Grifka: Orthopädie , 7th edition, Heidelberg, 2005, p. 101f.
