Chromogranins

Chromogranins ( English chromogranins ) describe a group of acidic proteins that were first found in vesicles of adrenaline and noradrenaline- producing cells of the adrenal medulla and that, together with ATP (see nucleotides ) and magnesium ions , are said to be involved in the storage of these substances within vesicles.

Studies have shown that chromogranins, as so-called secretogranins, are at least also involved in the vesicular storage of peptides in neurons and hormonal glands .

list

• Chromogranin A (CgA, CHGA), a specific parameter in the serum laboratory diagnostics of histologically detected neuroendocrine tumors
• Chromogranin B alias Secretogranin I (CgB, CHGB, SCG1)
• Secretogranin II (SgII, SCG2) (see also Secretoneurin )
• Secretogranin III (SgIII, SCG3)
• Secretogranin V (SgV, SCG5, SGNE1)

See also

• Vesiculin

literature

• NE Preece, M. Nguyen, M. Mahata, SK Mahata, NR Mahapatra, I. Tsigelny, DT O'Connor: Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. In: Regulatory Peptides . 118 (1-2), April 2004, pp. 75-87. doi: 10.1016 / j.regpep.2003.10.035 . PMID 14759560 .
• WB Huttner, HH Gerdes, P. Rosa: The granin (chromogranin / secretogranin) family. In: Trends in Biochemical Sciences. 16 (1), January 1991, pp. 27-30. doi: 10.1016 / 0968-0004 (91) 90012-K . PMID 2053134 .
• M. Stridsberg, RH Angeletti, KB Helle: Characterization of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods. In: The Journal of Endocrinology. 165 (3), June 2000, pp. 703-714. doi: 10.1677 / joe.0.1650703 . PMID 10828855 .
• M. Stridsberg, A. Pettersson, R. Hagman, C. Westin, O. Höglund: Chromogranins can be measured in samples from cats and dogs. In: BMC Research Notes. 7 (1), June 2014, p. 336. doi: 10.1186 / 1756-0500-7-336 . PMC 4055239 (free full text). PMID 24899097 .
• OV Höglund, R. Hagman, M. Stridsberg: Chromogranin A and cortisol at intraoperative repeated noxious stimuli: Surgical stress in a dog model. (PDF) . In: SAGE Open Medicine. 3 (0), March 27, 2015, 2050312115576432. doi: 10.1177 / 2050312115576432 . PMC 4679230 (free full text). PMID 26770773 .
• T. Srithunyarat, OV Höglund, R. Hagman, U. Olsson, M. Stridsberg, AS Lagerstedt, A. Pettersson: Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy. In: BMC Research Notes. 9 (1), August 2016, p. 381. doi: 10.1186 / s13104-016-2193-1 . PMC 4969733 (free full text). PMID 27484122 .
• T. Srithunyarat, R. Hagman, OV Höglund, U. Olsson, M. Stridsberg, S. Jitpean, AS Lagerstedt, A. Pettersson: Catestatin and vasostatin concentrations in healthy dogs. In: Acta Veterinaria Scandinavica. 59 (1), January 2017, p. 1. doi: 10.1186 / s13028-016-0274-8 . PMC 5210291 (free full text). PMID 28049540 .

Individual evidence

1. ↑ David Binas, A.-K. Schubert et al. a .: Perioperative management in patients with carcinoid syndrome / neuroendocrine neoplasia. In: Anästh Intensivmed Volume 61, 2020, pp. 16–24, here: p. 20.