Homeobox protein DLX-1

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DLX1
Identifier
Gene name (s) DLX1
External IDs

The homeobox protein DLX1 is a protein for which the existing in people DLX1 - gene coded.

function

The gene codes as a member of the homeobox transcription factor gene family, which are very similar to the “distal-less” genes of Drosophila . The encoded protein is located in the nucleus , where it could act as a transport regulator for the signals from several members of the TGF- β superfamily. The encoded protein may play a role in controlling facial skull stricture and the differentiation and existence of inhibitory neurons in the forebrain . The gene is in a configuration with other members of the gene family on the long arm of chromosome 2 . The transcription variants that result from alternative splicing and that code for various protein isoforms have already been described in more detail.

Individual evidence

  1. ↑ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al .: Cloning and characterization of two members of the vertebrate Dlx gene family . In: Proc Natl Acad Sci USA . 91, No. 6, April 1994, pp. 2250-4. doi : 10.1073 / pnas.91.6.2250 . PMID 7907794 . PMC 43348 (free full text).
  2. ↑ a b Entrez Gene: DLX1 distal-less homeobox 1 . Retrieved May 20, 2012.

literature

  • Letinic K, Zoncu R, Rakic ​​P: Origin of GABAergic neurons in the human neocortex. . In: Nature . 417, No. 6889, 2002, pp. 645-9. doi : 10.1038 / nature00779 . PMID 12050665 .
  • Strausberg RL, Feingold EA, Grouse LH, et al. : Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . In: Proc. Natl. Acad. Sci. USA . 99, No. 26, 2003, pp. 16899-903. doi : 10.1073 / pnas.242603899 . PMID 12477932 . PMC 139241 (free full text).
  • Chiba S, Takeshita K, Imai Y, et al. : Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. . In: Proc. Natl. Acad. Sci. USA . 100, No. 26, 2004, pp. 15577-82. doi : 10.1073 / pnas.2536757100 . PMID 14671321 . PMC 307610 (free full text).
  • Ota T, Suzuki Y, Nishikawa T, et al. : Complete sequencing and characterization of 21,243 full-length human cDNAs. . In: Nat. Genet. . 36, No. 1, 2004, pp. 40-5. doi : 10.1038 / ng1285 . PMID 14702039 .
  • Zhou QP, Le TN, Qiu X, et al. : Identification of a direct Dlx home domain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. . In: Nucleic Acids Res . 32, No. 3, 2004, pp. 884-92. doi : 10.1093 / nar / gkh233 . PMID 14769946 . PMC 373381 (free full text).
  • Gerhard DS, Wagner L, Feingold EA, et al. : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . In: Genome Res. . 14, No. 10B, 2004, pp. 2121-7. doi : 10.1101 / gr.2596504 . PMID 15489334 . PMC 528928 (free full text).
  • Rual JF, Venkatesan K, Hao T, et al. : Towards a proteome-scale map of the human protein-protein interaction network. . In: Nature . 437, No. 7062, 2005, pp. 1173-8. doi : 10.1038 / nature04209 . PMID 16189514 .
  • Hamilton SP, Woo JM, Carlson EJ, et al. : Analysis of four DLX homeobox genes in autistic probands. . In: BMC Genet. . 6, 2006, p. 52. doi : 10.1186 / 1471-2156-6-52 . PMID 16266434 . PMC 1310613 (free full text).