Darcin
| Darcin (major urinary protein 24) | ||
|---|---|---|
| Mass / length primary structure | 18894 Da, 181 amino acids | |
| Identifier | ||
| External IDs | ||
| Occurrence | ||
| Parent taxon | Rodents | |
Darcin is the new name for MUP24 ( major urinary protein 24), a protein of the lipocalin family in rodents , which has been shown to be not only the pheromone-active (S) -2-sec-butyl-4, 5-Dihydro-Thiazole (SBT) binds, but that itself is effective as a pheromone.
Darcin is formed in the liver, filtered through the kidney into the urine and not reabsorbed. In wild mice only the males have darcin, in domesticated and inbred C57Bl / 6 mice darcin was also found in the female urine.
The MUP gene locus shows 21 or 9 genes in mice and rats, 3 genes in horses and 2 genes in lemurs, 1 gene in other species: orangutans, chimpanzees, macaques, dogs or pigs and only one pseudogene in humans. Therefore, darcin in humans can be excluded.
See also
Individual evidence
- ↑ Swiss Institute of Bioinformatics (SIB): PROSITE documentation PDOC00187. Retrieved September 20, 2011 .
- ↑ a b Sarah Roberts, Deborah Simpson, Stuart Armstrong, Amanda Davidson, Duncan Robertson, Lynn McLean, Robert Beynon, Jane Hurst: Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odor . In: BMC Biology . 8, No. 1, 2010, p. 75. doi : 10.1186 / 1741-7007-8-75 .
- ↑ Darren W. Logan, Tobias F. Marton, Lisa Stowers: Species Specificity in Major Urinary Proteins by Parallel Evolution . In: PLoS ONE . 3, No. 9, 2008, p. E3280. doi : 10.1371 / journal.pone.0003280 .