De Ritis quotient

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The de Ritis quotient , introduced by de Ritis et al., Indicates the ratio of the liver enzymes aspartate aminotransferase (ASAT or GOT) and alanine aminotransferase (ALAT or GPT) in medicine , which is an indication of the underlying Liver disease .

calculation

Serum concentrations are used in each case.

The reference range of the dimensionless De Ritis quotient is 0.6-0.8.

rating

A small de-ritis quotient (<1) indicates less liver damage (e.g. virus hepatitis ), a large quotient (> 1) indicates more severe liver damage (e.g. chronic hepatitis , liver cirrhosis , often with alcoholism )

Extrahepatic diseases can also cause an abnormal de-ritis quotient. An increased quotient can be found in acute myocardial infarction (ASAT / ALAT> 1.3).

application

The de-ritis quotient is mainly used in liver diagnostics in order to be able to make a statement about the severity of liver cell damage or liver cell necrosis . ASAT is not liver-specific, but about 80% is in the mitochondria and about 20% in the cytoplasm . ALAT is almost liver-specific and has its highest activity in the hepatocytes : 20% of it is in the mitochondria and 80% in the cytoplasm. The more mitochondrial enzymes that are released, the more severe the hepatocyte damage.

If the liver values ​​are otherwise in the reference range, an increased De Ritis quotient is not very meaningful.

literature

  • Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, Mario Rizzetto: Textbook of Hepatology . 3. Edition. Wiley-Blackwell, 2007, ISBN 978-1-4051-2741-7 .
  • James William Keyser: Human Plasma Proteins: Their Investigation in Pathological Conditions . Wiley, Chichester 1987, ISBN 0-471-91587-4 .

Individual evidence

  1. ↑ Human Plasma Proteins: Their Investigation in Pathological Conditions . Wiley, Chichester 1987, ISBN 0-471-91587-4 , pp. 77 .
  2. ↑ Fernando de Ritis, M. Coltorti, G. Giusti: An enzymic test for the diagnosis of viral hepatitis: The transaminase serum activities . In: Clinica Chimica Acta . tape 369 , no. 2 , 1957, ISSN  0009-8981 , p. 148–152 , doi : 10.1016 / j.cca.2006.05.001 , PMID 16781697 .
  3. ↑ a b Arno Dormann, Thomaswege, Claus Luley: Laborwerte . 4th edition. Urban & Fischer at Elsevier, 2005, ISBN 3-437-22022-5 , p. 72 .
  4. ^ Matthias Lohr, Matthias Lohr Bernhard K Keppler: Internal medicine . 4th edition. Elsevier, Urban & Fischer-Verlag, Munich 2005, ISBN 3-437-42451-3 , chapter 4, p. 341 .
  5. ↑ a b Klaus Dörner, H.-J. Battista: Clinical Chemistry and Hematology . 6th edition. Georg Thieme Verlag, Stuttgart 2006, ISBN 3-13-129716-6 , chapter 14, p. 386 .