Dejerine-Spiller Syndrome

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The medial medullary syndrome , also Medial medullary syndrome (MMI), refers to an injury to the medulla oblongata with unilateral tongue paralysis due to failure of the hypoglossal nerve combined with mutual hypoesthesia and hemiparesis .

The name refers to the first description in 1908 by the US neurologist William Gibson Spiller and in 1914 by the French neurologist Joseph Jules Dejerine .

root cause

Occlusions of the anterior spinal artery and vertebral artery are assumed to be the cause .

Clinical manifestations

Clinical criteria are:

  • ipsilateral paralysis of the tongue (peripheral hypoglossal palsy) and
  • contralateral hemiparesis with hemihypesthesia.

pathology

Pathologically, there is a medial medulla oblongata lesion with failure of the hypoglossal nucleus as well as a lesion of the medial lemniscus with contralateral hemihypesthesia and a lesion of the basal pyramidal tract .

literature

  • P. Pergami, TE Poloni, F. Imbesi, M. Ceroni, F. Simonetti: Dejerine's syndrome or Spiller's syndrome? In: Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Vol. 22, No. 4, August 2001, pp. 333-336, ISSN  1590-1874 . PMID 11808859 .

Individual evidence

  1. ↑ WG Spiller: The symptom-complex of a lesion of the uppermost portion of the anterior spinal and adjoining portions of the vertebral arteries , in: Journal of Nerval and Mental Disease 1908, Vol 35, pp 775-778.
  2. ^ J. Dejerine: Semiologie des affections du systeme nerveux. Paris: Masson et Cie, 1914, p. 114.
  3. ↑ M. Krasnianski, M. Winterholler, S. Neudecker, S. Zierz: Classic alternating medulla oblongata syndrome. A historical-critical and topodiagnostic analysis , in: Advances in Neurology-Psychiatry. Vol. 71, No. 8, August 2003, pp. 397-405, ISSN  0720-4299 . doi : 10.1055 / s-2003-41192 . PMID 12910445 . (Review).

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