Derepression

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In genetics, derepression denotes the lifting of a repression of a gene .

properties

Not all genes are read at all times. Some genes are only transcribed in certain periods of time (e.g. during ontogenesis ) and in individual cell types (e.g. in individual tissues or organs ). Repression prevents the transcription of a gene, while derepression is the reverse process.

Derepression occurs by releasing a blocked gene, e.g. B. by binding an inducer to the repressor or by epigenetic modification. The bound inducer leads to a release of the repressor from the operator in the operon whose transcription is blocked. The derepressed operon can then lead to gene expression through transcription . Examples of derepression are the regulation of the transcription of the δ-aminolevulinate synthase or the receptor of the luteinizing hormone .

Incorrectly derepressed genes occur e.g. B. in cancer .

Web links

Individual evidence

  1. ↑ HM Jeong, MJ Kwon, YK Shin: Overexpression of Cancer-Associated Genes via Epigenetic Derepression Mechanisms in Gynecologic Cancer. In: Frontiers in Oncology . Volume 4, 2014, p. 12, ISSN  2234-943X . doi : 10.3389 / fonc.2014.00012 . PMID 24551595 . PMC 3912470 (free full text).
  2. ↑ K. Igarashi, M. Watanabe-Matsui: Wearing red for signaling: the heme-bach axis in heme metabolism, oxidative stress response and iron immunology. In: The Tohoku Journal of Experimental Medicine . Volume 232, Number 4, 2014, pp. 229-253, ISSN  1349-3329 . PMID 24681888 .
  3. ↑ ML Dufau, M. Liao, Y. Zhang: Participation of signaling pathways in the derepression of luteinizing hormone receptor transcription. In: Molecular and Cellular Endocrinology . Volume 314, Number 2, January 2010, pp. 221-227, ISSN  1872-8057 . doi : 10.1016 / j.mce.2009.05.005 . PMID 19464346 . PMC 2815110 (free full text).
  4. ↑ D. Gabellini, R. Tupler, MR Green: Transcriptional derepression as a cause of genetic diseases. In: Current Opinion in Genetics & Development . Volume 13, Number 3, June 2003, pp. 239-245, ISSN  0959-437X . PMID 12787785 .