Diversity (chemistry)
Diversity , also known as chemical diversity, is a measure of the diversity of the most varied of small chemical molecular structures within a chemical space or area and at the same time for the variance of different synthetic methods , especially in organic chemistry . Ideally, through a diversity-oriented synthesis (DOS), collectives of small molecules are obtained which, after screening (pharmaceuticals, crop protection, etc.), can be regionally and stereoselectively functionalized in order to be able to efficiently optimize the structures of potential active ingredients.
The products of a diversity-oriented synthesis represent a wide range of compounds with a broad distribution in chemical space, for which areas that are currently still weakly or not at all occupied should be found, which possibly correlate optimally with certain desired properties, for example as a medicinal substance .
Multicomponent reactions are often used to obtain a large variety of very different small chemical molecular structures.
Individual evidence
- ↑ Martin D. Burke, Stuart L. Schreiber: A strategy for diversity-oriented synthesis. In: Angewandte Chemie . 116, 2004, pp. 48-60.
- ↑ Jieping Zhu, Hugues Bienaymé (editor): Multicomponent Reactions. Wiley-VCH, ISBN 978-3-527-30806-4 .
- ↑ Nicolas Isambert, Rodolfo Lavilla: Heterocycles as Key Substrates in Multicomponent Reactions: The Fast Lane towards Molecular Complexity. In: Chemistry - A European Journal . 14, 2008, pp. 8444-8454, doi : 10.1002 / chem.200800473 .
- ↑ Daesung Lee, Jason K. Sello, and Stuart L. Schreiber: Pairwise Use of Complexity-Generating Reactions in Diversity-Oriented Organic Synthesis. In: Organic Letters 2 (2000) pp. 709-712.