Dopamine reuptake inhibitors

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Dopamine reuptake inhibitors ( DRI, Sorghum bicolor for D op a mine R euptake I nhibitors) are drugs that by blocking the dopamine transporter , the presynaptic uptake of the neurotransmitter dopamine inhibit and thus the extracellular increase concentration. DARI are used as stimulants and antidepressants for the treatment of depression , attention deficit disorders and obesity .

Medicines that only act as DARI have rarely come onto the market. Much more often , such drugs block the reuptake of noradrenaline at the same time and are accordingly referred to as selective noradrenaline / dopamine reuptake inhibitors (SNDRI) , e.g. B. Nomifensin . Triple reuptake inhibitors are also being developed.

Zinc is a natural dopamine reuptake inhibitor with a high level of selective binding to the dopamine transporter.

Active ingredients

See also

Individual evidence

  1. ↑ AM Koenig, ME Thase: First-line pharmacotherapies for depression - what is the best choice? In: Polskie Archiwum Medycyny Vewn? Trznej. Volume 119, Numbers 7-8, 2009 Jul-Aug, pp. 478-486, PMID 19776688 .
  2. ↑ SM Stahl: Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action. In: The Journal of clinical psychiatry. Vol. 59 Suppl 4, 1998, pp. 5-14, PMID 9554316 .
  3. ^ AR Matthews, OH He, M. Buhusi, CV Buhusi: Dissociation of the role of the prelimbic cortex in interval timing and resource allocation: beneficial effect of norepinephrine and dopamine reuptake inhibitor nomifensine on anxiety-inducing distraction. In: Frontiers in integrative neuroscience. Volume 6, 2012, p. 111, doi: 10.3389 / fnint.2012.00111 . PMID 23227004 . PMC 3512209 (free full text).
  4. ↑ Z. Chen, P. Skolnick: Triple uptake inhibitors: therapeutic potential in depression and beyond. In: Expert opinion on investigational drugs. Volume 16, Number 9, September 2007, pp. 1365-1377, doi: 10.1517 / 13543784.16.9.1365 . PMID 17714023 .
  5. ↑ C Pifl, A Wolf, P Rebernik, H Reither, ML Berger: Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner. In: Neuropharmacology , 2009 Feb, 56 (2), pp. 531-540, PMID 19000913 . Epub 2008 Oct 26.
  6. ↑ Lene Norregaard, Dorte Frederiksen, Elsebet Ø. Nielsen, Ulrik Gether: Delineation of an endogenous zinc-binding site in the human dopamine transporter . PMC 1170760 (free full text) (as PDF: 389 kB) In: The EMBO Journal . Vol. 17, No. 15, 1998, pp. 4266-4273.