Medifoxamine

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Structural formula
Structural formula of medifoxamine
General
Non-proprietary name Medifoxamine
other names
  • N , N -dimethyl-2,2-diphenoxyethylamine ( IUPAC )
  • Medifoxaminum ( Latin )
Molecular formula C 16 H 19 NO 2
External identifiers / databases
CAS number 32359-34-5
EC number 251-011-4
ECHA InfoCard 100.046.359
PubChem 36109
ChemSpider 33212
Wikidata Q544834
Drug information
ATC code

N06 AX13

Drug class

Antidepressants

properties
Molar mass 257.33 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
Toxicological data

750 mg kg −1 ( LD 50 ,  mouse ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Medifoxamine is a drug that was used to treat depression before it was withdrawn from the market . It acts as a dopamine reuptake inhibitor and as an agonist at the 5HT 2A and 5HT 2C receptors . The Merck - daughter Lipha sales medifoxamine as part of a drug under the trade name Cledial .

Medifoxamine was mainly used in France . It was withdrawn from the market in 1999 because of rare but severe cases of liver damage .

Web links

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Entry on medifoxamine in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on November 28, 2018.
  3. ^ S. Saleh, P. Turner: Ocular hypotensive effects of medifoxamine. In: Br J Clin Pharmacol . 34, 1992, pp. 269-271. PMID 1389953 .
  4. ↑ P. Martin, F. Lemonnier: Intérêt des récepteurs sérotoninergiques de type 2, 5-HT2A and 5-HT2C, dans les troubles dépressifs: action de la médifoxamine. In: Encephale. 20, 1994, pp. 427-435. PMID 7988407 .
  5. ^ PB Mitchell: Novel French antidepressants not available in the United States. In: Psychopharmacol Bull . 31, 1995, pp. 509-519. PMID 8668756 .
  6. ↑ Anonymous. Atteintes hépatiques sous médifoxamine. In: Prescrire. 19, 1999, pp. 591-592.
  7. ↑ G. Dumortier, W. Cabaret, L. Stamatiadis and others: Tolérance hépatique des antipsychotiques atypiques. In: Encephale. 28, 2002, pp. 542-551. PMID 12506267 .