Fibrous nasal papule

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Classification according to ICD-10
D23.3 Other benign neoplasms: skin of other and unspecified parts of the face
ICD-10 online (WHO version 2019)
A fibrous nasal papule

A fibrous papule of the nose ( engl. Fibrous papule of the nose ; ICD-O 8724/0) is a benign tissue formation ( neoplasia ), which is typically at the tip of the nose forms or on a nose. Locations of the fibrous papules outside the nasal area are rarer. In such cases one speaks of a fibrous face pile .

Description and diagnosis

The fibrous nasal papule is a hamartoma (a benign tumor-like tissue malformation), which usually occurs primarily in adults, regardless of age. However, cases have also been described in children aged four and over. The size of the firm and sharply demarcated papule (nodule) usually varies between 1 and 5 mm in diameter. It is skin-colored to slightly reddish and smooth on the surface. Fibrous nasal papules mainly form on the ala, on the nasal alar furrow or on the tip of the nose and are symptom-free . They occur individually (solitary) and remain stationary. The size can also remain constant over many years.

The fibrin-stabilizing factor XIIIa , a blood coagulation factor , plays an important role in the formation of a fibrous nasal papule. It is believed that a fibrous nasal papule is a variant of angiofibroma caused by dermal dendrocytes . These cells are positive for factor XIIIa. Occasionally they also contain multinuclear giant cells. Histopathologically, the fibrous nasal papule can be divided into different variants. There are clear-cell fibrous, inflammatory -fibrous, epithelial-fibrous, pigmented fibrous and pleiomorphic-fibrous variants.

Under certain circumstances, a biopsy may be necessary to differentiate a basalioma .

therapy

Fibrous nasal papules can be surgically excised through a flat excision . The papule at the level of the papillary dermis is removed with a tangential cut. An alternative is removal with a carbon dioxide laser .

further reading

Individual evidence

  1. ↑ a b c d H. Traupe, H. Hamm: Pediatrische Dermatologie. 2nd edition, Verlag Springer, 2006, ISBN 3-540-25646-6 , limited preview in the Google book search
  2. ↑ P. Altmeyer: Dermatological differential diagnosis - the way to clinical diagnosis. Verlag Springer, 2007, ISBN 3540390014 , p. 183. Restricted preview in the Google book search
  3. ^ AJ Nemeth, NS Penneys, HB Bernstein: Fibrous papule: a tumor of fibrohistiocytic cells that contain factor XIIIa. In: Journal of the American Academy of Dermatology Volume 19, Number 6, December 1988, pp. 1102-1106, ISSN  0190-9622 . PMID 2904927 .
  4. ↑ HS Park, S. Cho, KH Kim, CH Won: Fibrous papule of the face, clear cell type: a case report. In: Journal of the European Academy of Dermatology and Venereology Volume 21, Number 9, October 2007, pp. 1267-1268, ISSN  0926-9959 . doi : 10.1111 / j.1468-3083.2007.02160.x . PMID 17894726 .
  5. ^ AN Lee, SL Stein, LM Cohen: Clear cell fibrous papule with NKI / C3 expression: clinical and histologic features in six cases. In: The American Journal of Dermatopathology Volume 27, Number 4, August 2005, pp. 296-300, ISSN  0193-1091 . PMID 16121048 .
  6. ↑ C. Kucher, JM McNiff: Epithelioid fibrous papule - a new variant. In: Journal of Cutaneous Pathology Volume 34, Number 7, July 2007, pp. 571-575, ISSN  0303-6987 . doi : 10.1111 / j.1600-0560.2006.00667.x . PMID 17576337 .
  7. ↑ C. Bansal, D. Stewart, A. Li, CJ Cockerell: Histologic variants of fibrous papule. In: Journal of Cutaneous Pathology Volume 32, Number 6, July 2005, pp. 424-428, ISSN  0303-6987 . doi : 10.1111 / j.0303-6987.2005.00362.x . PMID 15953376 .
  8. ↑ a b M. Sand, D. Sand, C. Thrandorf, V. Paech, P. Altmeyer, FG Bechara: Cutaneous lesions of the nose. In: Head & face medicine Volume 6, 2010, p. 7, ISSN  1746-160X . doi : 10.1186 / 1746-160X-6-7 . PMID 20525327 . PMC 290354 (free full text). ( Review in Open Access ).
  9. ↑ CE Orfanos, C. Garbe: Therapy of skin diseases. Verlag Springer, 2002, ISBN 3-540-41366-9 , p. 923. Limited preview in the Google book search