ARF GTPase activating protein 1
| ARF GTPase activating protein 1 | ||
|---|---|---|
| other names |
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| Properties of human protein | ||
| Identifier | ||
| Gene name | GIT1 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 28964 | 216963 |
| Ensemble | ENSG00000108262 | ENSMUSG00000011877 |
| UniProt | Q9Y2X7 | Q68FF6 |
| Refseq (mRNA) | NM_001085454 | NM_001004144 |
| Refseq (protein) | NP_001078923 | NP_001004144 |
| Gene locus | Chr 17: 29.57 - 29.59 Mb | Chr 11: 77.49 - 77.51 Mb |
| PubMed search | 28964 |
216963
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When ARF GTPase-activating protein 1 is an enzyme that from GIT1 - gene is encoded. It serves as a GTPase-activating protein for the adenosyl-ribosylation factors (ARF) and possibly also as a scaffold to form other proteins that control vesicle transport , cell adhesion and the organization of the cytoskeleton . It also increases the rate of cell migration and the formation of cellular protuberances, probably by bringing PAK1 to cell adhesion and to the outer end of the pseudopod . It is also involved in the regulation of cytokinesis .
It plays an important role in Huntington's disease by promoting the clumping of altered huntingtin .
Individual evidence
- ↑ UniProt Q9Y2X7
- ^ R. Manabe, M. Kovalenko, DJ Webb, AR Horwitz: GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration . In: Journal of cell science . 115, No. 7, April 2002, pp. 1497-1510. PMC 11896197 (free full text).
- ↑ A protein promotes pathological deposits in chorea Huntington's disease protein interaction network led on the trail . Press release of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, September 24, 2004, accessed on October 8, 2015.