Non-Celiac Disease-Non-Wheat Allergy-Wheat Sensitivity

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The non-celiac gluten sensitivity (Syn .: wheat sensitivity , English non-celiac gluten sensitivity is NCGS, abbreviated) a wheat intolerance with one of celiac disease (inflammatory response of the intestinal mucosa to the "gluten" gluten ) clinically similar image despite exclusion an autoimmune reaction ( endomysium antibodies, tissue-specific transglutaminase antibodies) or a wheat allergy ( prick test , specific IgE ).

The cause is assumed to be innate immunity to alpha-amylase trypsin inhibitors (ATI). Approx. 20% of people may also be intolerant to the otherwise harmless fermentable oligo-, di-, monosaccharides and polyols (FODMAP) from legumes and some types of fruit, vegetables and cereals - including wheat.

There is currently no laboratory test procedure. Irritable bowel syndrome comes into consideration as a differential diagnosis , the complaints diary is groundbreaking here. The histological examination of the small intestinal mucosa often reveals unspecific eosinophilic infiltrates . Villus atrophy, such as celiac disease, is less common, so malabsorption is also less common. It is therefore currently a diagnosis of exclusion :

"In the case of a wheat-dependent clinic and negative serology (for celiac disease-specific antibodies ), normal small intestine histology , negative specific IgE (wheat) and negative prick test (wheat)."

"In children and adolescents, non-celiac disease-non-wheat allergy-wheat sensitivity should be proven or excluded by double-blind , placebo- controlled exposure in order to avoid negative psychosocial and nutritional consequences of a strictly gluten-free diet."

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