Glycogen synthases

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Dextrin chain extended by glycogen synthase

Glycogen synthases or starch synthases are those enzymes that lengthen dextrin chains by adding another glucose molecule. This is the penultimate step in the synthesis of glycogen and starch and is therefore indispensable for all living things that produce these reserves .

Three different types of glycogen synthases are known: the bacterial and plant ADP glycogen synthase ( EC  2.4.1.21 ), the plant granule-bound starch synthase ( EC  2.4.1.242 ) and the animal UDP glycogen synthase ( EC  2.4.1.11 ).

literature

  • E. Zeqiraj, F. Securei: Getting a handle on glycogen synthase - Its interaction with glycogenin. In: Molecular aspects of medicine. Volume 46, December 2015, pp. 63-69, doi : 10.1016 / j.mam.2015.08.004 , PMID 26278983 (review).
  • DC Palm, JM Rohwer, JH Hofmeyr: Regulation of glycogen synthase from mammalian skeletal muscle - a unifying view of allosteric and covalent regulation. In: The FEBS journal. Volume 280, number 1, January 2013, pp. 2-27, doi : 10.1111 / febs.12059 , PMID 23134486 (review).

Web links

Wikibooks: Biochemistry and Pathobiochemistry: Glycogen Synthesis  - Learning and Teaching Materials