Glycoprotein 2b / 3a Inhibitors

The glycoprotein 2b / 3a inhibitors (also: GP-IIb / IIIa inhibitors) work by blocking the GP-IIb / IIIa receptors on the surface of the platelets . In doing so, they inhibit the formation of blood clots.

They are used as platelet aggregation inhibitors - such as B. also clopidogrel , but instead of this substance - routinely used in balloon catheter operations on the coronary arteries with and without stent implantation and in acute coronary syndrome . The outcome after administration of the various GP-IIb / IIIa inhibitors is the same; the main risk with its use is bleeding. The drug group includes:

Individual evidence

↑ J. Kössler, U. Steigerwald, U. Walter: [Anticoagulants of primary haemostasis] . In: hemostaseology . tape 29 , no. 3 , August 2009, ISSN 0720-9355 , p. 274-278 , PMID 19644598 ( haemo.schattauer.de ). haemo.schattauer.de ( Memento of the original dated February 3, 2018 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2
↑ Michael Koutouzis, Bo Lagerqvist, Jonas Oldgren, Axel Åkerblom, Magnus Wahlin, Thomas Karlsson, Per Albertsson, Göran Matejka, Lars Grip: Long-Term Results Following Switch From Abciximab to Eptifibatide During Percutaneous Coronary Intervention . In: Clinical Cardiology . tape 33 , no. 11 , 2010, ISSN 1932-8737 , p. 686-692 , doi : 10.1002 / clc.20814 , PMID 21089113 .

[1] J. Kössler, U. Steigerwald, U. Walter: [Anticoagulants of primary haemostasis] . In: hemostaseology . tape 29 , no. 3 , August 2009, ISSN 0720-9355 , p. 274-278 , PMID 19644598 ( haemo.schattauer.de ). haemo.schattauer.de ( Memento of the original dated February 3, 2018 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2

[2] Michael Koutouzis, Bo Lagerqvist, Jonas Oldgren, Axel Åkerblom, Magnus Wahlin, Thomas Karlsson, Per Albertsson, Göran Matejka, Lars Grip: Long-Term Results Following Switch From Abciximab to Eptifibatide During Percutaneous Coronary Intervention . In: Clinical Cardiology . tape 33 , no. 11 , 2010, ISSN 1932-8737 , p. 686-692 , doi : 10.1002 / clc.20814 , PMID 21089113 .