Goitrogens

Goitrogenic or goiter-own substances are substances that cause the thyroid gland to enlarge ( goiter , "goiter"). In terms of their mechanism of action, they can be divided into two groups:

• Substances that inhibit iodine uptake ( iodination ) in the thyroid gland, as well
• Substances that inhibit the formation of organic iodine compounds ( iodization ).

Iodination inhibitors

The mustard oil glycosides (glucosinolates ) found in many types of cabbage ( Brassica spp.) Are partially converted in the body into thiocyanates , which reduce iodine absorption in the body. In addition, perchlorates have an iodination-inhibiting effect.

Iodine can be administered more therapeutically.

Iodization inhibitors

Thiooxazolidones , such as goitrin , are formed when mustard oil glycosides are broken down by mustard oils that contain a hydroxyl group in position 2 . The anti - thyroid drugs 2-thiouracil , methylthiouracil and propylthiouracil also prevent the iodination of tyrosine and thus the formation of thyroid hormones . Thyroid growth due to the ingestion of such substances can only be treated by administration of thyroid hormones.

literature

• Hans-Dieter Belitz et al .: Textbook of food chemistry . Springer, 5th edition 2001, ISBN 9783540410966 , p. 782.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !