Grading

This article explains the medical term, for the location in the district of Ried im Innkreis, Upper Austria, see Grading (municipality of Mettmach) , for the color grading of films see Color Correction .

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The term Grading ( English to grade , classify, organize in a ranking ') is in connection with the assessment of a tumor used to define the differentiation grade of the cancer tissue indicate d. H. the extent to which it deviates from normal tissues. This information, which is important for prognosis and therapy , is provided by the pathologist who examines a tissue sample (e.g. a biopsy ) under the microscope .

The UICC (Union Internationale Contre le Cancer) divides cancer cells into grades 1, 2, 3, sometimes 4 and 9 (there are no other grades).

• Grade 1 (G1): well-differentiated malignant tissue (“low-grade”), high agreement with the original tissue
• Grade 2 (G2): moderately differentiated malignant tissue
• Grade 3 (G3): poorly / poorly differentiated malignant tissue
• Grade 4 (G4): undifferentiated malignant tissue (undifferentiated or anaplastic ) ("high-grade"). Sometimes the tumor can no longer be assigned to a certain starting tissue or only on the basis of immunohistochemical examinations.
• Grade 9 (G9): Degree of differentiation cannot be assessed.

Usually, highly differentiated tumors (G1) show a much more favorable course than anaplastic tissue (G4). Important determining parameters here are the size and shape of the cell nuclei of the cells, their division activity and the similarity to the original tissue. However, specific criteria have been developed for most tumors. The aggressiveness of the tumor cannot be derived from the tumor size alone; the TNM classification and the UICC system alone are not very suitable.

Grading of brain tumors

→ Main article : WHO classification of central nervous system tumors

Grading of prostate tumors

→ Main article : Gleason score

Individual evidence

1. ↑ Microscopic diagnostics in cancer medicine: looking at tissue and cells - differentiation (grading): almost normal or particularly malignant? , Cancer Information Service of the German Cancer Research Center (DKFZ), Heidelberg. August 19, 2014. Last accessed September 4, 2014.

Web links

• Microscopic diagnostics in cancer medicine: looking at tissue and cells - differentiation (grading): almost normal or particularly malignant? , Cancer Information Service of the German Cancer Research Center (DKFZ), Heidelberg. August 19, 2014. Last accessed September 4, 2014.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !