Anaplasia

The Anaplasia means the advancement of higher differentiated cells in less differentiated cells. There is a strongly displaced nuclear-plasma relation , nuclear hyperchromasia and nucleoli enlargement .

The term was first used in 1893 by the German anatomist and pathologist David Paul von Hansemann for the absence or loss of differentiation of cells.

In tumors , anaplasia means that it is no longer possible to tell from which tissue an anaplastic tumor originated. The tumor cells are completely dedifferentiated. Anaplastic carcinomas are classified in the UICC (Union internationale contre le cancer) grading in grade 4, in brain tumors in grade III. They are highly malignant and often metastasize very early through the blood and lymph . The prognosis, however, depends on the tumor origin. The anaplastic astrocytoma for example, has a mean 5-year survival rate of approx. 31%, and anaplastic oligodendroglioma (also a brain tumor) with aggressive therapy has a slightly better prognosis.

See also

• Hyperplasia
• Neoplasia
• Dysplasia
• Metaplasia

Individual evidence

1. ↑ AllEx - The compendium for the 2nd ÄP. Volume B: Neurologie , Thieme (2012), pp. 902-903

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !