David Paul from Hansemann

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David Paul Hansemann around 1897
David Paul Hansemann in 1882
David Paul Hansemann with his son Fritz David, around 1892

David Paul Hansemann , from 1901 by Hansemann (born September 5, 1858 in Eupen , then Kingdom of Prussia , now Belgium , † August 28, 1920 in Berlin ) was a German pathologist . He formulated one of the first theories about the origin of cancer .

Career and work

David Paul came from a very wealthy family. He was the son of Gustav Hansemann (1829-1902), who was raised as a rentier in Charlottenburg with his descendants on January 18, 1901 in Berlin to the Prussian nobility , and Mathilde Vorländer (1827-1880). His grandfather was the merchant and banker David Hansemann . His uncle Adolph von Hansemann was one of the wealthiest men in the German Empire and his cousin was the chemist Daniel Vorländer .

In 1881 Hansemann graduated from the Friedrich-Wilhelms-Gymnasium in Berlin . In the same year he began studying medicine in Berlin. After three semesters he went to Kiel for one semester and Leipzig for three . His professors included Wilhelm His , Carl Ludwig , Ernst L. Wagner and Julius Friedrich Cohnheim . In 1886 Hansemann was promoted to Dr. med. PhD . After completing his studies and completing his military service, he became an assistant pathologist with Rudolf Virchow in Berlin. As part of his work there, in 1890 he reported noticeable changes in the cell nuclei and abnormal division patterns, which he had observed in slices of 13 different carcinomas . Hansemann saw a connection between these changes and the development of malignant tumors. He postulated that such aberrant cell divisions are responsible for both increased and decreased chromatin levels in cancer cells. His observations mark the beginning of tumor cytogenetics .

More than 20 years later, Theodor Boveri developed the chromosome hypothesis of tumor development based on Hansemann's observations and his own work : Changes in the chromosome set of a cell ( aneuploidy ) are the prerequisite for the transition from normal cell growth to malignant proliferation . Aneuploidy can be observed in a very large number of cancers. Whether aneuploidy is the cause or just the consequence of cancer is a matter of controversy. See also Peter Duesberg # aneuploidy cancer hypothesis .

In 1907, Hansemann examined the brains of Theodor Mommsen , Robert Bunsen and Adolf von Menzel ("Elite brain research").

Hansemann worked as a prosector at the Rudolf Virchow Hospital in Berlin ; around 1912 he was appointed secret medical councilor. In 1912 he became a full professor of pathology. During the First World War he was on the Eastern Front and received the Iron Cross First Class. He was with Elisabeth, geb. Walter (1863–1935), married and died of throat cancer in 1920 in Berlin. His son was the politician Fritz David von Hansemann (1886–1971).

The family grave has been preserved in the Old St. Matthew Cemetery .

Fonts

  • Microscopic diagnosis of malignant tumors. Publishing house August Hirschwald, Berlin 1902
  • The superstition in medicine and its danger to health and life. Teubner Publishing House, 1905; 2nd edition, 1914
  • Atlas of Malignant Tumors. Publishing house August Hirschwald, Berlin 1910

literature

Individual evidence

  1. ^ Mary F. Peterson, Leon P. Bignold, Hubertus PA Jersmann: Research into German medicine in the nineteenth century - the example of David Paul von Hansemann (1858-1920). (PDF; 235 kB) In: AGMB Annual Conference 2007 ISSN  1865-066X
  2. ^ Genealogisches Handbuch des Adels , Adelslexikon Volume IV, page 425, Volume 67 of the complete series, CA Starke Verlag, Limburg (Lahn) 1978
  3. ↑ a b Leon P. Bignold, Brian LD Coghlan, Hubertus PA Jersmann: David Paul von Hansemann: Contributions to Oncology. Context, Comments and Translations. Birkhäuser Verlag, 2007, ISBN 978-3-764-37769-4 . limited preview in Google Book search
  4. ^ David Paul von Hansemann. Retrieved April 16, 2011 from whonamedit.com
  5. ^ Paul A. Hardy, Helmut Zacharias: Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors. In: Cell Biology International Volume 29, Number 12, December 2005, pp. 983-992, ISSN  1065-6995 . doi : 10.1016 / j.cellbi.2005.10.001 . PMID 16314117 .
  6. ↑ David Hansemann: About asymmetrical cell healing in epithelial cancers and their biological significance. In: Virchows Arch Pathol Anat Physiol Klin Medicin Volume 119, 1890: pp. 299-326.
  7. ↑ David Hansemann: About the anaplasia of the tumor cells and the asymmetrical mitosis. In: Arch Pathol Anat Physiol Klin Medicin Volume 129, 1892: 436-449.
  8. ↑ B. Marte: Milestone 2: (1890) Cancer as a genetic disease. In: nature.com April 2006 doi : 10.1038 / nrc1844
  9. ↑ a b H. Zankl: Molecular cytogenetic tumor diagnostics. In: AM Raem, H. Fenger u. a. (Ed.): Gene medicine: an inventory. Verlag Springer, Berlin, Heidelberg 2000, ISBN 3-540-67393-8 , p. 253 restricted preview in the Google book search
  10. ↑ Joachim Oertel: Tumorzytogenetik. Saarland University Hospital, accessed on April 16, 2011.
  11. ↑ Theodor Boveri: On the question of the development of malignant tumors. Fischer, Jena: 1914.
  12. ↑ Peter Duesberg : The chaos in the chromosomes. In: Spectrum of Science , October 2007, pp. 55ff.
  13. ^ Jochen Richter: The Kaiser Wilhelm Institute for Brain Research and the Topography of the Cerebral Hemispheres. In: B. Von Brocke, H. Laitko (eds.): The Kaiser Wilhelm Society and its institutes. Verlag Walter de Gruyter, Berlin & New York 1996, ISBN 3-110-15483-8 , 349-408; there p. 377. limited preview in the Google book search
  14. ↑ David v. Hansemann: About the brains of Th. Mommsen, RW Bunsen and Ad v. Menzel. Stuttgart, 1907.
  15. ↑ Stefan Richter The teaching collection of the Zoological Institute of the Berlin University - its history and its meaning. ( Memento of the original from April 13, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved April 16, 2011 @1@ 2Template: Webachiv / IABot / www2.hu-berlin.de
personal data
SURNAME Hansemann, David Paul from
ALTERNATIVE NAMES Hansemann, David Paul
BRIEF DESCRIPTION German pathologist
DATE OF BIRTH September 5, 1858
PLACE OF BIRTH Eupen , at that time the Kingdom of Prussia
DATE OF DEATH August 28, 1920
Place of death Berlin