Haber-Weiss reaction
The Haber-Weiss reaction is a name reaction in organic chemistry that was named after Fritz Haber (1868–1934) and his academic student Joseph Joshua Weiss (1905–1972). The reaction generates hydroxyl radicals (• OH) from hydrogen peroxide (H 2 O 2 ) and dioxide (1−) (• O 2 - ). This reaction can take place in cells and is therefore a potential source of oxidative stress . The reaction is very slow, but is catalyzed by Fe 3+ ions.
mechanism
In the first step of the reaction cycle , the dioxide (1−) is oxidized to oxygen . Fe 3+ is reduced to Fe 2+ :
The second step is known as the Fenton reaction . In this case, hydrogen peroxide in hydroxyl radicals and hydroxide ions split while Fe 2+ ion to Fe 3+ oxidized is.
swell
- JP Kehrer: The Haber-Weiss reaction and mechanisms of toxicity. In: Toxicology Volume 149, Number 1, August 2000, pp. 43-50, PMID 10963860 .