Harold Frost

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Harold M. Frost ( 1921 - June 19, 2004 ) was an American orthopedist and surgeon . He is regarded as one of the most important researchers and theorists in the field of bone biology and medicine of his time. Frost published nearly 500 scientific articles and 16 books. According to the Science Citation Index , he is one of the most cited authors in his field.

His main scientific contributions included:

  • The development of bone Histo morphometry to describe bone formation and degradation processes at the cellular level
  • The eleventh rib biopsy to diagnose metabolic bone disease
  • The study of the multicellular unit as the key to bone metabolism
  • The experimental evidence that estrogen reduces bone formation
  • The histological evidence of microcracks in human bone biopsies
  • The basic model of the adaptation of the growth plate of the bone according to the mechanical stimuli acting on it
  • The Utah paradigm of bone physiology ( Mechanostat theorem), which, as an extension of Wolff's law, describes the adaptation of the bone to mechanical stimuli and thus the relationship between muscle and bone.

Books by Harold M. Frost

  • Bone remodeling dynamics. The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1963.
  • The laws of bone structure. The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1964.
  • Mathematical Elements of Lamellar Bone Remodelling. The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1964.
  • Bone biodynamics. Henry Ford Hospital international symposium, [14], Little, Brown (Boston) 1964.
  • The bone dynamics in osteoporosis and osteomalacia. The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1966.
  • An introduction to biomechanics. Surgical monographs, Thomas (Springfield, Ill.), 1967, ISBN 0-398-02824-9 .
  • Orthopedic surgery in spasticity. (= Orthopedic lectures. Vol. 1). Thomas (Springfield, Ill.), 1972.
  • The physiology of cartilaginous, fibrous, and bony tissue. (= Orthopedic lectures. Vol. 2). Thomas (Springfield, Ill.), 1972, ISBN 0-398-02562-2 .
  • Bone remodeling and its relationship to metabolic bone diseases. (= Orthopedic lectures. Vol. 3). Thomas (Springfield, Ill.), 1973, ISBN 0-398-02588-6 .
  • Bone modeling and skeletal modeling errors. (= Orthopedic lectures. Vol. 4). Thomas (Springfield, Ill.), 1973, ISBN 0-398-02667-X .
  • Orthopedic Biomechanics. (= Orthopedic Lectures. Vol. 5). Thomas (Springfield, Ill.), 1973, ISBN 0-398-02824-9 .
  • Symposium on the Osteoporoses Part 1: Physioplogy, Pathophysiology, and Diagnosis. Saunders (Philadelphia), 1981.
  • Symposium on the Osteoporoses Part 2: Therapy and Prevention. Saunders (Philadelphia), 1981.
  • Intermediary organization of the skeleton. CRC Press (Boca Raton, Fla), 1986, ISBN 0-8493-5948-1 .
  • Bone in clinical orthopedics - Chapter 14: Determinants of bone strength and mass: a summary and clinical implications. by Geoff Sumner-Smith, Georg Thieme Verlag, 2002, ISBN 0-86577-829-9 , books.google.de
  • The Utah Paradigm of Skeletal Physiology. Vol. 1. ISMNI, 2004.
  • The Utah Paradigm of Skeletal Physiology. Vol. 2. ISMNI, 2004.

Individual evidence

  1. ↑ a b c C. Turner, D. Burr, WS Jee, S. Smith, RR Recker, DW Axelrod, HE Takahashi, AR Villanueva, WB High, RB Martin, AM Parfitt: Tribute to Harold M. Frost MD In: J Musculoskeletal Neuron Interact. 4 (4), 2004, pp. 348-356. PMID 15758257
  2. ↑ RR Recker: In memoriam: Harold M. Frost, MD, Dr. Sc. Hon., Orthopedist. In: Bone. 35 (3), Sep 2004, p. 581. PMID 15729783
  3. ↑ WS Jee: Harold M. Frost, MD, D.Sc. (hon) - one man's association. In: J Musculoskelet Neuronal Interact. 6 (2), Apr-Jun 2006, pp. 113-121. PMID 16849819

Web links

personal data
SURNAME Frost, Harold
ALTERNATIVE NAMES Frost, Harold M.
BRIEF DESCRIPTION American orthopedist and surgeon
DATE OF BIRTH 1921
DATE OF DEATH June 19, 2004