Hibernation Induction Trigger

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Hibernation Induction Trigger (HIT) is a hormone found in marmots in 1978 and later in other animals that hibernate . The substance appears to have opioid- like effects. In experimental studies, the substance has shown an improved tolerance of various tissues, for example the heart muscle, to ischemia .

The subject of current research is to use the hormone to counteract human muscle wasting in the hospital bed or reperfusion damage after a lack of oxygen. But not only the muscle strength of bedridden patients should be maintained by the hormone , the substance could also be of interest to astronauts , because they also have problems with their muscles during prolonged weightlessness . HIT also appears to accelerate the healing of accidental injuries , increase the lifespan of donor organs , reduce osteoporosis , and have a beneficial effect on patients with diabetes mellitus .

Individual evidence

  1. ↑ PR Oeltgen et al .: Isolation of a hibernation inducing trigger (s) from the plasma of hibernating woodchucks. In: Prep Biochem. (1978), Volume 8, Issue 2-3, pp. 171-188. PMID 568785 .
  2. ↑ CV Borlongan, Y. Wang, TP Su: Delta opioid peptide (D-Ala 2, D-Leu 5) enkephalin: linking hibernation and neuroprotection. In: Frontiers in bioscience: a journal and virtual library. Volume 9, September 2004, pp. 3392-3398, ISSN  1093-4715 . PMID 15353366 .
  3. ↑ ND Horton et al .: Isolation and partial characterization of an opioid-like 88 kDa hibernation-related protein. In: Comp Biochem Physiol B Biochem Mol Biol. (1998), Volume 119, Issue 4, pp 787-805. PMID 9787770 .
  4. ^ SF Bolling et al .: Hibernation triggers and myocardial protection. In: Circulation (1998), Volume 98 (19 Suppl), pp. II220-3; discussion II223-4. PMID 9852906 .
  5. ↑ HR Bouma, EM Verhaag, JP Otis, G. Heldmaier, SJ Swoap, AM Strijkstra, RH Henning, HV Carey: Induction of torpor: mimicking natural metabolic suppression for biomedical applications. In: Journal of Cellular Physiology . Volume 227, Number 4, April 2012, pp. 1285-1290, ISSN  1097-4652 . doi : 10.1002 / jcp.22850 . PMID 21618525 .