Hill coefficient
The Hill coefficient n H indicates the slope of the curve of the binding of an inhibitor or a substrate in the Hill diagram (also known as the Hill plot ) and represents a means of measuring the cooperativity of the substrate binding of an enzyme .
With positive cooperativity, the Hill coefficient is between one and the number of substrate-specific binding sites . The larger the Hill coefficient, the stronger the cooperativity. If the Hill coefficient is less than one, one speaks of negative cooperativity. n H = 1 means no cooperativity.
This has been investigated particularly well using the example of the oxygen binding of hemoglobin .
Individual evidence
- ↑ a b Entry on Hill coefficient. In: Römpp Online . Georg Thieme Verlag, accessed on December 3, 2011.