Imino acids

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1-pyrroline-5-carboxylic acid, an N-substituted imino acid.

In chemistry, an imino acid describes a group of substances whose representatives have an imine and a carboxylate group .

properties

Imino acids have a similar structure to amino acids . The enzyme proline dehydrogenase ( PRODH / POX ) oxidizes proline to imino acid ( S ) -Δ 1 -pyrroline-5-carboxylic acid (P5C). Imino acids can be absorbed in the intestine by the permease hPAT1 ( human proton-coupled amino acid transporter 1 , synonym SLC36A1 ).

The amino acids proline and hydroxyproline have a secondary amine and were formerly known as imino acids, but the name is out of date. In the past, imido acids were also referred to as imino acids.

Web links

Individual evidence

  1. ↑ a b c Entry on Imino acids . In: IUPAC Compendium of Chemical Terminology (the “Gold Book”) . doi : 10.1351 / goldbook.I02959 Version: 2.3.3.
  2. ^ W. Liu, JM Phang: Proline dehydrogenase (oxidase) in cancer. In: BioFactors. Volume 38, number 6, 2012 Nov-Dec, pp. 398-406, doi : 10.1002 / biof.1036 . PMID 22886911 .
  3. ↑ CM Anderson, DS Grenade, M. Boll, M. Foltz, KA Wake, DJ Kennedy, LK Munck, S. Miyauchi, PM Taylor, FC Campbell, BG Munck, H. Daniel, V. Ganapathy, DT Thwaites: H + / amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient / drug transporter in human and rat. In: Gastroenterology. Volume 127, Number 5, November 2004, pp. 1410-1422, PMID 15521011 .
  4. ↑ MeSH imino acids
  5. ^ Amino Acids ( Memento of January 18, 2008 in the Internet Archive ).