Intimin
| Intimin ( Escherichia coli O157: H7) | ||
|---|---|---|
| Mass / length primary structure | 934 amino acids | |
| Secondary to quaternary structure | Transmembrane protein | |
| Identifier | ||
| Gene name (s) | eae | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 1.B.54.1.1 | |
| designation | Intimin / Invasin family | |
| Occurrence | ||
| Parent taxon | pathogenic E. coli ; Citrobacter spp. | |
Intimin is a protein , the pathogenic Escherichia coli strains and bacteria of the genus Citrobacter by secretion is excreted. It is necessary for the bacterium to stick ( adherence ) to the intestinal mucosa so that it is one of the adhesins . It also functions as a membrane channel in intestinal cells, with the help of which the bacterium can smuggle in further proteins.
Intimin gets to the surface of the bacterial cell with the help of the type III secretion system . For the overall process leading to lesions, further proteins of the bacterium are required.
Intimin belongs to a family of transport proteins, which also includes the invasive Yersinia bacteria.
Differences between humans and cattle
While enterohaemorrhagic colitis can develop in humans as the infection progresses , the lack of a receptor in cattle contributes to the possibility of excreting such bacteria without symptoms and transferring them to the human food chain via their manure . The complex process can also have a pathogenic effect on animals.
Web links
Individual evidence
- ^ TCDB entry Intimin / Invasin family
- ↑ Intimin from enteropathogenic Escherichia coli mediates remodeling of the eukaryotic cell surface
- ↑ Studies on the immunomodulating effect of the virulence factor 'Intimin' of enteropathogenic and enterohaemorrhagic Escherichia coli in cattle
- ↑ Serotypes, intimin variants and other virulence factors of eae positive Escherichia coli strains isolated from healthy cattle in Switzerland. Identification of a new intimin variant gene (eae-η2)
- ↑ Intimin and the host cell - is it bound to end in Tir (s)?