Jörg S. Hartig

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Jörg Steffen Hartig (born December 12, 1974 ) is a German chemist (chemistry and synthetic biology of nucleic acids ).

From 1994 Hartig studied chemistry at the University of Bonn with a diploma in 2000 under Michael Famulok , from which he also received his doctorate in 2003 (Reporter ribozymes for detection of biomolecular interactions). Until 2005, he was a post-doctoral student at Stanford University with Eric T. Kool . From 2006 he was Lichtenberg Professor (a junior professorship donated by the Volkswagen Foundation) for the chemistry of biologically functional materials at the University of Konstanz , where he has been professor for biopolymer chemistry since 2011.

It synthesizes RNA in a modular way with combined functions, for example in the regulation of gene expression (riboswitch, RNA interference), as an aptamer (antibody-like binding function) and ribozyme . As part of synthetic biology, he also develops RNA that can be controlled and switched from the outside, e.g. by coupling small molecules (e.g. as aptamers). He is also investigating the use of four-stranded guanine-rich RNA (quadruplexes) for the regulation of biological processes.

In 2011 he received the Chemistry Prize of the Academy of Sciences in Göttingen for groundbreaking and pioneering work on the chemical biology of nucleic acids and especially RNA (laudation). In 2015 he received an ERC Consolidator Grant.

Fonts (selection)

  • with Michael Famulok u. a .: Protein-dependent ribozymes report molecular interactions in real time, Nature Biotechnology, Volume 20, 2002, p. 717
  • with Michael Famulok, Günter Mayer: Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy, Chemical Reviews, Volume 107, 2007, p. 3715
  • with Markus Wieland: Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme, Angewandte Chemie International Edition, Volume 45, 2006, p. 5875
  • Teaching Bacteria new Tricks - with RNA Switches (highlight), Angewandte Chemie International Edition, Volume 46, 2007, p. 7741
  • with Markus Wieland: RNA quadruplex-based modulation of gene expression, Chemistry & Biology, Volume 14, 2007, p. 757
  • with Simon Ausländer u. a .: A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression, Molecular Biosystems, Volume 6, 2007, p. 807
  • with Markus Wieland: Improved aptazyme design and in vivo screening enable riboswitching in bacteria, Angewandte Chemie, Volume 47, 2008, p. 2604
  • with Markus Wieland: Artificial Riboswitches: Synthetic mRNA-based Regulators of Gene Expression, ChemBioChem, Volume 9, 2008, p. 1873
  • with Markus Wieland, Armin Benz, Benedikt Klauser: Artificial ribozyme switches containing natural riboswitch aptamer domains, Angewandte Chemie, Volume 48, 2009, p. 2616
  • with Astrid Joachimi, Armin Benz: A comparison of DNA and RNA quadruplex structures and stabilities, Bioorganic & Medicinal Chemistry, Volume 17, 2009, p. 6811
  • with Patrick Ketzer u. a .: Artificial riboswitches for gene expression and replication control of DNA and RNA viruses, Proc. Nat. Acad. Sci. USA, Volume 111, 2014, E554
  • with Simon Ausländer u. a .: A general design strategy for protein-responsive riboswitches in mammalian cells, Nature Methods, Volume 11, 2014, p. 1154

Web links

Individual evidence

  1. ↑ Hartig, Jörg S. In: Kürschner's German Scholars Calendar Online. De Gruyter. Retrieved April 12, 2019.
personal data
SURNAME Hartig, Jörg S.
ALTERNATIVE NAMES Hartig, Jörg Steffen (full name)
BRIEF DESCRIPTION German chemist
DATE OF BIRTH December 12, 1974