Jochen Look

Jochen Guck (* 1973 in Germany ) is a German biophysicist.

Guck studied physics at the University of Würzburg with a diploma in 1997 and received his doctorate in 2001 at the University of Texas at Austin and from 2002 was junior group leader and scientific assistant at the University of Leipzig (Institute for Soft Matter Physics). In 2007 he became a Lecturer and in 2009 Reader at Cambridge University (Cavendish Laboratory). In 2012 he received a Humboldt Professorship for cellular machines at the Biotechnological Center of the TU Dresden . Since October 2018 he has been director at the Max Planck Institute for the Science of Light and at the Max Planck Center for Physics and Medicine in Erlangen, where he heads a research group in the field of "Biological Optomechanics".

He investigates the mechanical and optical properties of cells and tissues with applications in medicine (diagnosis, regenerative medicine). He also developed new methods, for example in biophotonics (application of Optical Diffraction Tomography (ODT), Quantitative Phase Imaging (QPI)), where he used the distribution of the internal refractive index (RI) of the cell as a biomarker for differentiation, cancer or Infection takes advantage. He investigates the mechanics of cells with atomic force microscopy and the methods developed by him or at his laboratory, real-time deformability cytometry (RT-DC) and the optical stretcher (an optical trap in which cells are deformed without contact with light ).

He received the Young Scientist Award in Biomedical Photonics from the German Cancer Research Center Heidelberg.

Fonts (selection)

• with R. Ananthakrishnan a. a .: Optical deformability of soft biological dielectrics, Physical Review Letters, Volume 84, 2000, p. 5451
• with R. Ananthakrishnan a. a .: The optical stretcher: a novel laser tool to micromanipulate cells, Biophysical Journal, Volume 81, 2001, pp. 767-784
• with B. Lincoln a. a .: Deformability-based flow cytometry, Cytometry Part A, Volume 59, 2004, pp. 203-209
• with F. Wottawah a. a .: Optical rheology of biological cells, Phys. Rev. Letters, Volume 94, 2005, p. 098103
• with S. Schinkinger u. a .: Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence, Biophysical Journal, Volume 88, 2005, pp. 3689-3698
• with YB Lu u. a .: Viscoelastic properties of individual glial cells and neurons in the CNS, Proceedings of the National Academy of Sciences, Volume 103, 2006, pp. 17759-17764
• with K. Franze u. a .: Müller cells are living optical fibers in the vertebrate retina, Proceedings of the National Academy of Sciences, Volume 104, 2007, pp. 8287-8292
• with B. Lincoln a. a .: Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications, Biomedical Microdevices, Volume 9, 2007, pp. 703-710 (Optical Stretcher)
• with TW Remmerbach u. a .: Oral cancer diagnosis by mechanical phenotyping, Cancer Research, Volume 69, 2009, pp. 1728-1732
• with I. Solovei a. a .: Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution, Cell, Volume 137, 2009, pp. 356-368
• with F. Lautenschläger u. a .: The regulatory role of cell mechanics for migration of differentiating myeloid cells, Proc. Nat. Acad. Sci. USA, Volume 106, 2009, pp. 15696-15701
• with Andreas Christ u. a .: Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy, Journal of Biomechanics, Volume 43, 2010, pp. 2986-2992
• with K. Franze, PA Janmey: Mechanics in neuronal development and repair, Annual Review of Biomedical Engineering, Volume 15, 2013, pp. 227-251

Web links

• Look department at the Max Planck Institute for the Science of Light.
• Peeplab
• Humboldt Professorship for Look