José Antonio López Guerrero

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José Antonio López Guerrero (2016)

José Antonio López Guerrero (* 1962 in Madrid ) is a Spanish virologist .

Guerrero works as a University Professor of Microbiology in the Department of Molecular Biology at the Universidad Autónoma de Madrid and Director of Culture and Science at the Center for Molecular Biology Severo Ochoa (Centro de Biología Molecular Severo Ochoa - CBMSO). He is also active in various scientific programs on radio, press and television.

education

After completing school in Hanover and at the IES Cervantes (Madrid), López Guerrero studied biochemistry at the Universidad Autónoma de Madrid (1980–1985). In 1990 he received a special award for his doctoral thesis in the field of immunovirology at the CBMSO. After completing his doctorate, he spent two research stays at the Centro de Investigaciones Biológicas (Madrid, CIB-CSIC, 1990–1993) and at the German Cancer Research Center (DKFZ, 1993–1996). After his return to the UAM, he worked as an assistant professor and was responsible for public relations in the context of scientific research. Since 2001 he has been a permanent university professor at UAM and since 2003 head of a small research area in neurobiology . From 2003–2006 he founded the UAM's Department of Culture and Science and since 2006 he has been heading the department of the same name at the CBMSO.

research

  • Doctorate (1986–1989. CBMSO. Madrid): Study on the susceptibility of immune cells to virus infection.
  • First postdoc (1990–1993. CIB. Madrid): Analysis of rheumatoid arthritis in a mouse model.
  • Second postdoc (1993–1996. DKFZ ): Analysis of the promonocytic U937 cell clones selected for their resistance to Parvovirus H-1 infection.
  • Since 1996 (CBMSO UAM-CSIC): HSV-1 infection and neurodegeneration.

Awards

  • 2011: Spanish radio, Radio 5 and Radio 1 programs "A Hombros de Gigantes" (On the shoulders of giants): Award for the scientific publications "Science in Action" and "Safir-Vallehermoso".
  • 2012: "Scientific Communication Award Blogs Mi + d" from Madri + d Foundation (TV program).
  • 2014: " ANTAMA Prize" in recognition of his work for scientific communication in biotechnology in Spain.
  • 2014: Second prize in the radio category in the third edition of the ASEBIO Prize for Communication in Biotechnology.
  • 2016: "Special Jury Prize" " Science in Action ".
  • 2017: ASEBIO special price.
  • 2018: Fundación Gestión del Conocimiento "Special Prize in recognition of his work for scientific communication in Spain".
  • 2019: Honor roll of the AEC (Spanish Association of Scientists).
  • 2020: "Lupa Escéptica" award from ARP-SAPC.

Publications

  • ¿Qué es un Transgénico? (y las madres que lo parieron). 2nd Edition. Ed. Sirius, Madrid 2008, ISBN 978-84-92509-02-7 .
  • Células Madre: la madre de todas las células . Ed. Hélice, Madrid 2003, ISBN 84-933933-7-1 .
  • La Tesis de Rebeca. Apuntes de una joven investigadora. 2nd Edition. Ed. Hélice, Madrid 2009, ISBN 978-84-936196-3-3 .
  • Sé lo que ocurrió… los cursos pasados . Ed. Hélice, Madrid 2006, ISBN 1-4492-0864-9 .
  • Células madre y terapia regenerativa . RANF, 2009.
  • Ciencia en grageas . Turpial, 2012.
  • Ciencia exprés . Elam Editores. 2013.
  • Virus: ni vivos ni muertos . Guadalmazán. 2018 (2019 second edition).

Scientific Article

  • JA López-Guerrero, L. Carrasco, F. Martínez-Abarca, M. Fresno, MA Alonso: Restriction of poliovirus RNA translation in a human monocytic cell line. In: Eur. J. Biochem. Volume 186, 1989, pp. 577-582.
  • JA López-Guerrero, JP López-Bote, MA Ortíz, E. Páez, C. Bernabeu: Recombinant vaccinia virus for human heat shock protein ameliorates adjuvant arthritis. In: Infect. Immune. Volume 61, 1993, pp. 4225-4231.
  • JA López-Guerrero, MA Ortíz, E. Páez, C. Bernabeu, JP López-Bote: Therapeutic effect of the recombinat vaccinia virus expressing the 60-kilodanton heat shock protein on adjuvant arthritis. In: Arth. Rheumatism. Volume 37, 1994, pp. 1462-1467.
  • JA López-Guerrero, B. Rayet, M. Tuynder, J. Rommelaere, C. Dinsart: Constitutive activation of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection. In: Blood. Volume 89, 1997, pp. 1642-1653.
  • R. Hass, JA López-Guerrero: Aggressive tumor growth of human TUR leukemia cells is associated with high levels of c-Myc expression and down regulation of p20-Max. In: Int. J. Cancer. Volume 72, 1997, pp. 1-4.
  • JA López-Guerrero, L. Carrasco: Effect of nitric oxide on poliovirus infection of two human cell lines. In: J. Virol. Volume 72, 1998, pp. 2538-2540.
  • B. Rayet, JA López-Guerrero, J. Rommelaere, C. Dinsart: Induction of programmed cell death by parvovirus H-1 in U-937 cells: connection with the tumor necrosis factor alpha signaling patway. In: J. Virol. Volume 72, 1998, pp. 8893-8903.
  • JA López-Guerrero, M. Alonso, F. Martin-Belmonte, L. Carrasco: Poliovirus induces apoptosis in the human promonocytic cell line U937. In: Virology. Volume 272, 2000, pp. 250-256.
  • JA López-Guerrero, F. Martin-Belmonte, L. Carrasco, MA Alonso: The N-myristoylated nine amino acid sequence from the amino terminus of poliovirus capsid VP4 protein is sufficient for targeting to perinuclear structures containing detergent-insoluble membranes. In: Biochemistry. Volume 39, 2000, pp. 1083-1090.
  • M. Alonso, A. Dimitrijevic, M. Recuero, E. Serrano, F. Valdivieso, JA López-Guerrero: Interaction of alpha-2-macroglobulin and HSV-1 during infection of neuronal cells. In: J. NeuroVirol. Volume 7, 2001, pp. 556-563.
  • R. Bello-Morales, M. Fedetz, A. Alcina, E. Tabarés, JA López-Guerrero: High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection. In: J. NeuroVirol. Volume 11, 2005, pp. 190-198.
  • R. Bello-Morales, MC de Marco, JF Aranda, F. Matesanz, A. Alcina, JA López-Guerrero: Characterization of the MAL2 positive compartment in oligodendrocytes. In: Exp. Cell. Res. Volume 315, 2009, pp. 3453-3465. doi: 10.1016 / j.yexcr.2009.08.003
  • R. Bello-Morales, M. Pérez-Hernández, MT Rejas, F. Matesanz, A. Alcina, JA López-Guerrero: Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG. In: PLoS One. Volume 6, 2011, p. E19388. doi: 10.1371 / journal.pone.0019388
  • R. Bello-Morales, AJ Crespillo, A. Fraile-Ramos, E. Tabarés, A. Alcina, JA López-Guerrero: Role of the small GTPase Rab27a during Herpes simplex virus infection of oligodendrocytic cells. In: BMC Microbiol. Volume 12, 2012, p. 265. doi: 10.1186 / 1471-2180-12-265
  • R. Bello-Morales, AJ Crespillo, B. García, L. Á. Dorado, B. Martín, E. Tabarés, C. Krummenacher, F. de Castro, JA López-Guerrero: The effect of cellular differentiation on HSV-1 infection of oligodendrocytic cells. In: PLoS One. Volume 9, 2014, p. E89141. doi: 10.1371 / journal.pone.0089141
  • AJ Crespillo, B. Praena, R. Bello-Morales, L. Lerma, A. Vázquez-Calvo, MA Martín-Acebes, E. Tabarés, F. Sobrino, JA López-Guerrero: Inhibition of herpes virus infection in oligodendrocyte cultured cells by valproic acid. In: Virus Res. Volume 2, 2016, p. 214. doi: 10.1016 / j.virusres.2016.01.009
  • R. Bello-Morales, AJ Crespillo, B. Praena, E. Tabarés, Y. Revilla, E. García, A. Fraile-Ramos, W. Baron, C. Krummenacher, JA López-Guerrero: Role of Proteolipid Protein in HSV -1 entry in oligodendrocytic cells. In: PLoS One. Volume 11, 2016, p. E0147885. doi: 10.1371 / journal.pone.0147885
  • F. Matesanz, M. Fedetz, C. Barrionuevo, M. Karaky, A. Catalá-Rabasa, V. Potenciano, R. Bello-Morales, JA López-Guerrero, A. Alcina: A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria. In: Eur J Hum Genet. Volume 24, 2016, p. 1572. doi: 10.1038 / ejhg.2016.54
  • EG Sánchez, E. Riera, M. Nogal, C. Gallardo, P. Fernández, R. Bello-Morales, JA López-Guerrero, CG Chitko-McKown, JA Richt, Y. Revilla: Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production. In: Sci Rep. Volume 7, 2017, p. 10369. doi: 10.1038 / s41598-017-09948-x
  • R. Bello-Morales, B. Praena, C. de la Nuez, MT Rejas, M. Guerra, M. Galán-Ganga, M. Izquierdo, V. Calvo, C. Krummenacher, JA López-Guerrero: Role of Microvesicles in the Spread of Herpes Simplex Virus 1 in Oligodendrocytic Cells. In: J Virol. Volume 92, 2018, pp. E00088-18. doi: 10.1128 / JVI.00088-18
  • R. Bello-Morales, JA López-Guerrero: Extracellular Vesicles in Herpes Viral Spread and Immune Evasion. In: Front Microbiol. Volume 9, 2018, p. 2572. doi: 10.3389 / fmicb.2018.02572 . eCollection 2018.
  • B. Praena, R. Bello-Morales, F. de Castro, JA López-Guerrero: Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes. In: Antiviral Res. Volume 168, 2019, pp. 91-99. doi: 10.1016 / j.antiviral.2019.05.006 . Epub 2019 May 25.
  • M. Gil, R. González-González, A. Vázquez-Calvo, A. Álvarez-Gutiérrez, MA Martín-Acebes, B. Praena, R. Bello-Morales, JC Saiz, JA López-Guerrero, E. Tabarés, F Sobrino (2019): Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP. In: J Clin Med. Volume 8, No. 9, p. E1442. doi: 10.3390 / jcm8091442
  • R. Bello-Morales, JA López-Guerrero: Isolation / Analysis of Extracellular Microvesicles from HSV-1-Infected Cells. In: Methods Mol Biol. Volume 2060, 2020, pp. 305-317. doi: 10.1007 / 978-1-4939-9814-2_17

Web links

personal data
SURNAME López Guerrero, José Antonio
BRIEF DESCRIPTION Spanish virologist
DATE OF BIRTH 1962
PLACE OF BIRTH Madrid