Juvenile Polyposis Syndrome
| Classification according to ICD-10 | |
|---|---|
| D12 | Benign neoplasm of the colon, rectum, anal canal, and anus |
| D12.6 | Colon, unspecified - Polyposis coli (hereditary) |
| ICD-10 online (WHO version 2019) | |
In juvenile polyposis syndrome (JPS), also known as juvenile polyposis for short, so-called hamartomatous intestinal polyps ( polyp , hamartoma , tumor ) develop , which are mostly located in the colon, but also in the rest of the gastrointestinal tract. Can affect tract.
Juvenile polyps are the most common polyps in childhood. The majority are sporadic solitary polyps. In a small proportion, however, the polyps are a symptom of an autosomal dominant hereditary disease, known as familial juvenile polyposis (FJP), which is caused by mutations in the regulator protein MAD homolog 4 .
Pathophysiology and pathology
The juvenile polyps show hyperplastic-inflammatory changes in the mucous membrane on the surface and are generally considered to be benign. In rare cases there is a transition to true adenomatous polyps ( colorectal adenomas ), which are associated with an increased risk of colon cancer. Regular colon cancer screening, which should include the entire gastrointestinal tract, is therefore recommended, particularly in the familial form.
