Carcinogenicity index

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The carcinogenicity index (KI) is the difference between the sum of the mass content (in percent) of the oxides of sodium, potassium, boron, calcium, magnesium, barium and twice the mass content (in percent) of aluminum oxide. The AI ​​is intended to provide an indication of the solubility of substances, especially fibers, in living beings, such as humans.

The solubility in living things is called biosolubility. Low biosolubility, i.e. H. a high bio-persistence, is a factor that increases the carcinogenicity of fibers (certain shape and size) . Fibers are considered critical if they have the following dimensions: length> 5 μm, diameter <3 μm and length: diameter> 3: 1. The half-life is used to assess bio-resistance . A long half-life means high bio-stability, i.e. low bio-solubility. A high KI value indicates a high biosolubility and a short half-life and suggests low carcinogenicity. A high KI value is given if the fibers consist of a relatively large proportion of oxides of sodium, potassium, boron, calcium, magnesium, barium and a relatively low proportion of aluminum oxide. Glassy fibers with a KI of 30 and below are classified as "carcinogenic in animal experiments" (Category 2) Fibers with a KI between 30 and 40 are suspected of causing cancer (Category 3). Fibers with a KI 40 or greater are not classified as carcinogenic.

During the development of the KI value - around 1993 - doubts arose as to whether this approach is really suitable for classification, as fibers with high aluminum oxide contents would be wrongly classified as carcinogenic with the KI value. In 2017, the Gütegemeinschaft Mineralwolle decided to no longer allow the KI value to be used as an exemption for the fibers.

See also

Health aspects of mineral wool

Individual evidence

  1. ↑ EU Directive 67/548 / EEC Annex VI: GENERAL REQUIREMENTS FOR THE CLASSIFICATION AND LABELING OF DANGEROUS SUBSTANCES AND PREPARATIONS, 4.2 Classification criteria and selection of the indications of danger and the names of particular dangers, 4.2.1. Carcinogenic substances.
  2. ↑ TRGS 905 : List of carcinogenic, mutagenic or reproductive-endangering substances. of July 2005. In: BAnz. No. 148 of September 30, 2008, p. 3514.
  3. ↑ Dirk Diederich, Tanja Butt, Jörg Reipke: Chemical analyzes for the classification of artificial mineral wool: the carcinogenicity index KI alone is not sufficient here. (PDF; 1.2 MB) In: Analytik News. April 12, 2017. Retrieved June 15, 2018 .

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