Combination preparation

As combination products ( Composita ) are drugs referred to several active ingredients contained.

The combination of active ingredients results in an improved main effect or an expansion of the spectrum of activity. The fixed combination of several active ingredients required for effectiveness enables simple, effective and safe use.

Examples:

• The combination of a sulfonamide with trimethoprim extends the antibiotic spectrum of activity.
• The ovulation inhibitors are only effective through the fixed combination of a progestogen with an estrogen .

If a medicinal product contains more than one active ingredient, the application for approval must justify the fact that each active ingredient contributes to the positive assessment of the medicinal product.

The fixed combination of several active ingredients is viewed critically for some areas of application in the self-medication sector.

Individual evidence

1. ↑ Lippold, Müller-Goymann, Schubert: Pharmaceutical Technology . 10th edition. Wissenschaftliche Verlagsgesellschaft Stuttgart, Stuttgart 2017, ISBN 978-3-8047-3268-1 , p. 7 .
2. ↑ Michael von Wolff, Petra Stute: Gynecological endocrinology and reproductive medicine: The practice book . Schattauer Verlag, 2013, ISBN 978-3-7945-2792-2 .
3. ↑ Directive 2001/83 / EC (Community Code for Human Medicinal Products) , implemented in Germany in Section 22 of the Medicines Act .
4. ↑ Gerd Glaeske : OTC criticism re-reloaded . apotheke adhoc, October 5, 2015.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !